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Klaus Ley

University of California San Diego · US
Area of research
Immunology · Immunology and Allergy
Research interest
Research interests include Cell Adhesion Molecules Research, Atherosclerosis and Cardiovascular Diseases, Immune Response and Inflammation, and Neutrophil, Myeloperoxidase and Oxidative Mechanisms.
h-index
137
citations
77,896
works
968
NIH funding
primary concept
Medicine
email

Recent publications

Loss of effector Treg signature in APOB-reactive CD4+ T cells in patients with coronary artery disease
Nature Cardiovascular Research 2025cited by 4position: lastdoi
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Nature Metabolism 2024cited by 56position: middledoi
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis
Nature Cardiovascular Research 2023cited by 71position: middledoi
Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes
JCI Insight 2023cited by 38position: middledoi
V<sub>4</sub>C<sub>3</sub> MXene Immune Profiling and Modulation of T Cell‐Dendritic Cell Function and Interaction
Small Methods 2023cited by 34position: middledoi
V<sub>4</sub>C<sub>3</sub> MXene Immune Profiling and Modulation of T Cell‐Dendritic Cell Function and Interaction (Small Methods 8/2023)
Small Methods 2023cited by 0position: middledoi
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
Science 2022cited by 222position: lastdoi
Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
Cardiovascular Research 2022cited by 171position: middledoi
Molecular mechanisms of leukocyte β2 integrin activation
Blood 2022cited by 63position: lastdoi
Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease
Circulation Research 2022cited by 51position: middledoi
Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease
Nature Cardiovascular Research 2022cited by 46position: lastdoi
The expanding family of neutrophil‐derived extracellular vesicles
Immunological Reviews 2022cited by 40position: lastdoi
Immune Profiling and Multiplexed Label‐Free Detection of 2D MXenes by Mass Cytometry and High‐Dimensional Imaging
Advanced Materials 2022cited by 36position: middledoi
Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
BMC Biology 2022cited by 33position: lastdoi
Immune Profiling and Multiplexed Label‐Free Detection of 2D MXenes by Mass Cytometry and High‐Dimensional Imaging (Adv. Mater. 45/2022)
Advanced Materials 2022cited by 0position: middledoi
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Nature reviews. Immunology 2021cited by 523position: lastdoi
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq
Cardiovascular Research 2021cited by 137position: lastdoi
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain
The Journal of Experimental Medicine 2021cited by 101position: middledoi
CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
Nature Communications 2021cited by 73position: lastdoi
A CD22‐Shp1 phosphatase axis controls integrin β <sub>7</sub> display and B cell function in mucosal immunity
The FASEB Journal 2021cited by 0position: middledoi
T cell subsets and functions in atherosclerosis
Nature Reviews Cardiology 2020cited by 693position: lastdoi
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
Circulation Research 2020cited by 377position: lastdoi
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B <sub>100</sub> –Reactive CD4 <sup>+</sup> T-Regulatory Cells
Circulation 2020cited by 154position: lastdoi
Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages
Frontiers in Immunology 2020cited by 71position: lastdoi
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
The Journal of Experimental Medicine 2020cited by 54position: lastdoi
Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2
Trends in Microbiology 2020cited by 47position: middledoi
Biocompatibility studies of macroscopic fibers made from carbon nanotubes: Implications for carbon nanotube macrostructures in biomedical applications
Carbon 2020cited by 39position: middledoi
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages
Frontiers in Immunology 2019cited by 2,064position: lastdoi
Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns
Trends in Immunology 2019cited by 134position: middledoi
Circulating T cell-monocyte complexes are markers of immune perturbations
eLife 2019cited by 112position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

· 12 papers (2018–2023)Holger Winkels · University of Cologne7 papers (2018–2021)Yanal Ghosheh · La Jolla Institute for Immunology6 papers (2019–2022)Catherine C. Hedrick · Augusta University6 papers (2017–2022)Akula Bala Pramod · Indian Agricultural Research Institute6 papers (2016–2020)Lucia Gemma Delogu · University of Padua5 papers (2020–2023)Dennis Wolf · NIHR Leicester Biomedical Research Centre5 papers (2017–2020)Zbigniew Mikulski · Institute of Immunology5 papers (2013–2020)Alessandro Sette · University of California System5 papers (2013–2025)Alex Márki · Georgetown University5 papers (2015–2022)Christopher E. Shuck · Pennsylvania State University4 papers (2022–2023)Clément Cochain · Inserm4 papers (2018–2022)Yury Gogotsi · Nanomaterials Research (United States)4 papers (2022–2023)Yury I. Miller · University of San Diego4 papers (2012–2021)Laura Fusco · University of Padua4 papers (2022–2023)Barbara Zavan · University of Padua4 papers (2022–2023)Sara McArdle · National Imaging Facility4 papers (2012–2020)Arianna Gazzi · University of Padua4 papers (2022–2023)Konrad Buscher · La Jolla Institute for Immunology4 papers (2017–2020)Davide Bedognetti · Tumaini University4 papers (2022–2023)