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Josie E. Parker

Swansea University · GB
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Area of research
Infectious Diseases · Pharmacology
Research interest
Research interests include Biology, Sterol, Microbiology, Azole, Ergosterol, and Candida albicans.
h-index
citations
3,248
works
60
NIH funding
primary concept
email

Recent publications

Acquired amphotericin B resistance attributed to a mutated <i>ERG3</i> in <i>Candidozyma auris</i>
Antimicrobial Agents and Chemotherapy 2025cited by 7position: middledoi
Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 4position: middledoi
Exploring medium and long arm extensions of 1,2,4-triazole derivatives as <i>Candida albicans</i> 14α-demethylase (CYP51) inhibitors
RSC Medicinal Chemistry 2025cited by 2position: middledoi
A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
Nature Communications 2024cited by 42position: middledoi
The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
Nature Communications 2024cited by 27position: middledoi
Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complex
mBio 2024cited by 14position: middledoi
Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance
PLoS ONE 2024cited by 5position: middledoi
Genetic interaction analysis of <i>Candida glabrata</i> transcription factors <i>CST6</i> and <i>UPC2A</i> in the regulation of respiration and fluconazole susceptibility
Antimicrobial Agents and Chemotherapy 2024cited by 2position: middledoi
Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in <i>ERG2</i> as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr
Microbiology Spectrum 2023cited by 13position: middledoi
Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complex
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 3position: middledoi
The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 2position: middledoi
Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids
PLoS ONE 2022cited by 5position: middledoi
Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status
mBio 2022cited by 5position: middledoi
In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris
Clinical Microbiology and Infection 2021cited by 120position: middledoi
Loss-of-Function <i>ROX1</i> Mutations Suppress the Fluconazole Susceptibility of <i>upc2A</i> Δ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis
mSphere 2021cited by 14position: middledoi
Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure
Cronfa (Swansea University) 2021cited by 7position: first
Insights in the molecular mechanisms of an azole stress adapted laboratory-generated <i>Aspergillus fumigatus</i> strain
Medical Mycology 2021cited by 4position: middledoi
<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 2position: middledoi
Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i> Δ mutation in <i>Candida glabrata</i> , implicating additional positive regulators of ergosterol biosynthesis
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 1position: middledoi
Mutations in <i>TAC1B</i> : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris
mBio 2020cited by 196position: middledoi
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Nature Communications 2020cited by 149position: middledoi
Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis
International Journal of Pharmaceutics 2020cited by 24position: middledoi
Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against <i>Candida albicans</i>
ChemMedChem 2020cited by 23position: middledoi
Erratum for Kannan et al., “Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae <i>”</i>
mBio 2020cited by 4position: middledoi
Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 4position: middledoi
Mutations in <i>hmg1</i> , Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
mBio 2019cited by 120position: middledoi
Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae
mBio 2019cited by 69position: middledoi
The Evolution of Azole Resistance in <i>Candida albicans</i> Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
Antimicrobial Agents and Chemotherapy 2019cited by 57position: middledoi
Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens
International Journal of Antimicrobial Agents 2019cited by 18position: middledoi
Comparative genomics for the elucidation of multidrug resistance (MDR) in <i>Candida lusitaniae</i>
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 1position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Steven L. Kelly · Georgia Institute of Technology46 papers (2012–2025)Diane Kelly · Swansea University24 papers (2012–2025)Andrew G. S. Warrilow · Swansea University23 papers (2012–2025) · 16 papers (2015–2025) · 11 papers (2017–2025)Claire Price · Swansea University11 papers (2014–2022)Steve L. Kelly · Swansea University10 papers (2013–2021)W. David Nes · Swansea University9 papers (2014–2019) · 7 papers (2015–2021)Christina A. Cuomo · Massachusetts Institute of Technology7 papers (2020–2025)Glen E. Palmer · University of Tennessee at Knoxville6 papers (2017–2022)Dominique Sanglard · University of Lausanne6 papers (2012–2021)Claire M. Hull · Swansea University5 papers (2012–2014)Nicola J. Rolley · Swansea University5 papers (2014–2022) · 4 papers (2021–2025) · 4 papers (2018–2023) · 4 papers (2019–2024) · 4 papers (2019–2024)W. Scott Moye‐Rowley · University of Iowa3 papers (2020–2021)Sandra Asner · University of Lausanne3 papers (2019–2020)
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