Area of research
Infectious Diseases · Pharmacology
Research interest
Research interests include Biology, Sterol, Microbiology, Azole, Ergosterol, and Candida albicans.
Acquired amphotericin B resistance attributed to a mutated <i>ERG3</i> in <i>Candidozyma auris</i>
Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>
Exploring medium and long arm extensions of 1,2,4-triazole derivatives as <i>Candida albicans</i> 14α-demethylase (CYP51) inhibitors
A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complex
Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance
Genetic interaction analysis of <i>Candida glabrata</i> transcription factors <i>CST6</i> and <i>UPC2A</i> in the regulation of respiration and fluconazole susceptibility
Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in <i>ERG2</i> as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr
Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complex
The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids
Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status
In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris
Loss-of-Function <i>ROX1</i> Mutations Suppress the Fluconazole Susceptibility of <i>upc2A</i> Δ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis
Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure
Cronfa (Swansea University) 2021cited by 7position: first
Insights in the molecular mechanisms of an azole stress adapted laboratory-generated <i>Aspergillus fumigatus</i> strain
<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>
Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i> Δ mutation in <i>Candida glabrata</i> , implicating additional positive regulators of ergosterol biosynthesis
Mutations in <i>TAC1B</i> : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis
Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against <i>Candida albicans</i>
Erratum for Kannan et al., “Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae <i>”</i>
Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>
Mutations in <i>hmg1</i> , Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae
The Evolution of Azole Resistance in <i>Candida albicans</i> Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens
Comparative genomics for the elucidation of multidrug resistance (MDR) in <i>Candida lusitaniae</i>