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Dan Theodorescu

University of Arizona · US
Area of research
Surgery · Pulmonary and Respiratory Medicine
Research interest
Research interests include Bladder and Urothelial Cancer Treatments, Epigenetics and DNA Methylation, Prostate Cancer Treatment and Research, and Urinary and Genital Oncology Studies.
h-index
85
citations
30,497
works
789
NIH funding
primary concept
email

Recent publications

Predicting response to neoadjuvant chemotherapy in muscle-invasive bladder cancer via interpretable multimodal deep learning
npj Digital Medicine 2025cited by 25position: middledoi
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Nature 2025cited by 24position: lastdoi
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Nature 2025cited by 24position: selecteddoi
Basu M, Xiao J-F, Kailasam Mani SK, Qu F, Lin Y, Duex J, Ye H, Neang V, Theodorescu D . 2025. Genes driving three-dimensional growth of immortalized cells and cancer . Cell Death & Disease. Article number: 442(16).
2025cited by 0position: selected
The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients.
2024cited by 39position: selecteddoi
Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy.
2024cited by 5position: selecteddoi
Feldman LER, Mohapatra S, Jones RT, Scholtes M, Tilton CB, Orman MV, Joshi M, Deiter CS, Broneske TP, Qu F, et al. 2024. Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy . Science Advances. 10(50).
2024cited by 0position: selected
Osipov A, Nikolic O, Gertych A, Parker S, Hendifar A, Singh P, Filippova D, Dagliyan G, Ferrone CR, Zheng L, et al. 2024. The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients . Nature Cancer. 5(2):299–314.
2024cited by 0position: selected
Bladder cancer
Nature Reviews Disease Primers 2023cited by 455position: lastdoi
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Nature 2023cited by 161position: selecteddoi
Non-muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin.
2023cited by 56position: selecteddoi
<scp>CD24</scp> targeting with <scp>NK‐CAR</scp> immunotherapy in testis, prostate, renal and (luminal‐type) bladder cancer and identification of direct <scp>CD24</scp> interaction partners
FEBS Journal 2023cited by 15position: middledoi
Abdel-Hafiz HA, Schafer JM, Chen X, Xiao T, Gauntner TD, Li Z, Theodorescu D . 2023. Y chromosome loss in cancer drives growth by evasion of adaptive immunity . Nature. 619(7970):624–631.
2023cited by 0position: selected
de Jong FC, Laajala TD, Hoedemaeker RF, Jordan KR, van der Made AC, Boevé ER, van der Schoot DK, Nieuwkamer B, Janssen EA, Mahmoudi T, et al. 2023. Non–muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin . Science Translational Med
2023cited by 0position: selected
FimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer
Journal for ImmunoTherapy of Cancer 2022cited by 26position: middledoi
Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti–PD-L1 Immune Checkpoint Therapy
JNCI: Journal of the National Cancer Institute 2022cited by 13position: selecteddoi
Assessment of Luminal and Basal Phenotypes in Bladder Cancer
Scientific Reports 2020cited by 170position: middledoi
Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Cancer Research 2017cited by 31position: lastdoi
Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study
Clinical Cancer Research 2016cited by 104position: middledoi
An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression
Cancer Cell 2016cited by 79position: middledoi
<i>TERT</i> promoter mutations and telomerase reactivation in urothelial cancer
Science 2015cited by 295position: middledoi
Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
Oncogene 2015cited by 138position: middledoi
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Science Translational Medicine 2014cited by 5,064position: middledoi
<i>TERT</i> promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Proceedings of the National Academy of Sciences 2013cited by 1,369position: middledoi
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Nature Genetics 2013cited by 509position: middledoi
Frequent truncating mutations of STAG2 in bladder cancer
Nature Genetics 2013cited by 224position: middledoi
Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization
Clinical Cancer Research 2013cited by 78position: lastdoi
Discovery and validation of urinary biomarkers for detection of renal cell carcinoma
Journal of Proteomics 2013cited by 72position: middledoi
Telomerase in Bladder Cancer: Back to a Better Future?
European Urology 2013cited by 10position: firstdoi
ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for Urothelial Carcinoma—Neoadjuvant and Adjuvant Settings
European Urology 2012cited by 170position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Dan Theodorescu · University of Arizona6 papers (2022–2025)Donna E. Hansel · The University of Texas MD Anderson Cancer Center3 papers (2016–2023)Garrett M. Dancik · University of Colorado Denver3 papers (2015–2017)Antonia Vlahou · National and Kapodistrian University of Athens2 papers (2013–2016)Korbinian Brand · Medizinische Hochschule Hannover2 papers (2013–2016)William Mullen · University of Glasgow2 papers (2013–2016)Harald Mischak · Medizinische Hochschule Hannover2 papers (2013–2016)Arlene O. Siefker‐Radtke · The University of Texas MD Anderson Cancer Center2 papers (2012–2013)David J. McConkey · Johns Hopkins University2 papers (2020–2025) · 2 papers (2013–2020)Shahrokh F. Shariat · University Hospital in Motol2 papers (2012–2013)Woonyoung Choi · Johns Hopkins University2 papers (2020–2025) · 2 papers (2013–2020)Tokameh Mahmoudi · Springer Nature2 papers (2023–2024)Hany A. Abdel-Hafiz · University of Arizona2 papers (2023–2025)Tahlita C.M. Zuiverloon · Erasmus MC Cancer Institute2 papers (2023–2024)James C. Costello · Stanford University2 papers (2023–2024)Colin P. Dinney · The University of Texas MD Anderson Cancer Center2 papers (2020–2025) · 2 papers (2013–2016) · 2 papers (2013–2016)