Area of research
Neurology · Physiology
Research interest
Research interests include Alzheimer's disease research and treatments, Parkinson's Disease Mechanisms and Treatments, Neurological diseases and metabolism, and Genetic Associations and Epidemiology.
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging.
GPNMB and glycosphingolipid measurements in cerebrospinal fluid and plasma from Parkinson's disease patients
Divergent consequences of PSEN1 knockout and PSEN2 knockout in stem cell derived models of the brain
Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts.
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.
Author Correction: TMEM175, SCARB2 and CTSB associations with Parkinson's disease risk across populations.
Plasmalogen deficiency and the Alzheimer's disease risk of apolipoprotein E4.
Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease.
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
Genetic modifiers of APOE-ε4-associated cognitive decline
Genome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology.
Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality.
Alzheimer's Disease: Treatment Challenges for the Future
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations
Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks
Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer's disease.
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure.
Amelioration of signaling deficits underlying metabolic shortfall in TREM2<sup>R47H</sup> human iPSC-derived microglia.
Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.
Machine learning in Alzheimer’s disease genetics
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
The regulatory rollercoaster continues-EMA refuses donanemab.
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.
The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder.
Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores.
Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementia
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis.
The LRRK2 p.L1795F variant causes Parkinson's disease in the European population.