Area of research
Genetics · Pulmonary and Respiratory Medicine
Research interest
My research is directed towards the deveiopment of new therapies for brain tumors and leptomeningeal metastases using gene therapy, inhibitors of angiogenesis, hormonal therapy and radionuclides. I am also interested in the neurologic complications in cancer patients.
Associations of supramaximal resection with outcome in glioblastoma across age groups: A report of the RANO resect group.
Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma.
Characterization of focal leptomeningeal extension in patients with brain metastases: A novel entity.
Evaluation of sex differences in survival among glioblastoma patients treated with immune checkpoint inhibitors.
Evaluation of Regorafenib in Newly Diagnosed and Recurrent Glioblastoma: GBM AGILE Phase II/III Bayesian Randomized Platform Trial.
STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.
CNS tumor type prevalence according to age group: An analysis of 21 000 cases confirmed by methylation profiling, with a focus on adolescents and young adults
Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas
RANO criteria for response assessment of brain metastases based on amino acid PET imaging
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas
Contemporary prognostic signatures and refined risk stratification of gliomas: An analysis of 4400 tumors.
Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care
RANO criteria for response assessment of brain metastases based on amino acid PET imaging.
Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection-Update 1.
Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standard for PET imaging of brain metastases: version 1.0
Leptomeningeal metastatic disease: new frontiers and future directions.
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
Benchmarking the efficacy of salvage systemic therapies for recurrent meningioma: A RANO group systematic review and meta-analysis to guide clinical trial design.
Vorasidenib in IDH1-mutant or IDH2-mutant low-grade glioma (INDIGO): secondary and exploratory endpoints from a randomised, double-blind, placebo-controlled, phase 3 trial
Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care.
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses
Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial.
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.
Point/Counterpoint: The role of reirradiation in recurrent glioblastoma.
Response Assessment in Neuro-Oncology (RANO) 2009–2025: Broad scope and implementation—A progress report
Canonical amplifications and CDKN2A/B loss refine IDH1/2-mutant astrocytoma prognosis.
The use of minor response, volumetric assessment, and growth rate kinetics as endpoints in grade 1-3 glioma clinical trials: a RANO perspective
Phase I Study of Adavosertib with Radiotherapy and Temozolomide in Newly Diagnosed Glioblastoma and Intratumoral Drug Levels in Recurrent Glioblastoma
Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report.