Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include DNA Repair Mechanisms, Genomics and Chromatin Dynamics, Microtubule and mitosis dynamics, and DNA and Nucleic Acid Chemistry.
Cell integrity limits ploidy in budding yeast
Distinct RPA functions promote eukaryotic DNA replication initiation and elongation
DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
Initiation-specific alleles of the Cdc45 helicase-activating protein
Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis
Transcriptional repression of CDC6 and SLD2 during meiosis is associated with production of short heterogeneous RNA isoforms
Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
Nucleosomes influence multiple steps during replication initiation
Rethinking origin licensing
Replication origin–flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence
Chromosome Duplication in<i>Saccharomyces cerevisiae</i>
Single‐Molecule Studies of Eukaryotic DNA Replication
Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading
The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-Molecule Level
Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation
A conserved MCM single-stranded DNA binding element is essential for replication initiation
Terminating the replisome
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy
Mechanism of Eukaryotic Helicase Loading and Activation