Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include RNA modifications and cancer, Cancer-related molecular mechanisms research, MicroRNA in disease regulation, and Air Quality and Health Impacts.
Developing adverse outcome pathways underlying CAR activation-induced liver injuries using HepG2 spheroid model.
Coke Oven Emission Exposure Triggers Malignant Transformation of Lung Epithelial Cells by <i>SFTA1P</i>-Dependent Alteration of Acetyl-CoA Metabolism.
Correction: LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma.
piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma.
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease
An entropy weight method to integrate big omics and mechanistically evaluate DILI.
Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> from Molecule to Health Risk.
Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation.
Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes
Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the <i>PLIN2</i> promoter.
Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM<sub>2.5</sub>-induced lung cancer development.
Genomic Characterization Revealed PM<sub>2.5</sub>-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B.
Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk.
Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma
105P A single-arm, phase II, multicenter study of iparomlimab (QL1604) in patients (pts) with unresectable/metastatic deficient mismatch repair (dMMR)/microsatellite instability high (MSI-H) solid tumors
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury.
GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation
Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests
N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro.
PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A.
miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer.
The path via pathway-based approaches towards safety assessment: A concise review.
Additional file 4 of Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
Additional file 2 of Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
Additional file 3 of Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
Additional file 5 of Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure
High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages
PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury