Area of research
Immunology · Hematology
Research interest
Research interests include Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Immune Response and Inflammation, Immune Cell Function and Interaction, and Immune cells in cancer.
Multiphoton intravital microscopy of rodents
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis
Platelet-Neutrophil Interplay: Insights Into Neutrophil Extracellular Trap (NET)-Driven Coagulation in Infection
Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Immune Responses in the Liver
Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment
Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD
α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature
A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury
Platelets in inflammation and infection
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
Immune surveillance by the liver
Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps
Platelets: bridging hemostasis, inflammation, and immunity
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection
Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies
Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo
Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis