Area of research
Molecular Biology · Computational Theory and Mathematics
Research interest
Research interests include Receptor Mechanisms and Signaling, Protein Degradation and Inhibitors, Bioactive Natural Diterpenoids Research, and Computational Drug Discovery Methods.
Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB
Efficient <i>in vivo</i> pharmacological inhibition of ΔFOSB, an AP1 transcription factor, in brain
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
FeNi-modified carbon nanotube arrays on silicon carbide fibers for electromagnetic wave absorption
Therapeutic potential of salicylamide derivatives for combating viral infections
Allosteric inhibitors of the main protease of SARS-CoV-2
Antiviral Agents against Flavivirus Protease: Prospect and Future Direction
Chemically targeting the redox switch in AP1 transcription factor ΔFOSB
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition
Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer
Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer
Small-molecule inhibitors for the Prp8 intein as antifungal agents
In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
Molecular targeting therapies for neuroblastoma: Progress and challenges
JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both <i>In Vitro</i> and <i>In Vivo</i>
AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence
Modulation of Bax and mTOR for Cancer Therapeutics
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs
Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
Small-molecule Bax agonists for cancer therapy