Area of research
Genetics · Hematology
Research interest
Research topics from publications: The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter; Novel deoxyribonucleic acid methylation perturbations in workers exposed to vinyl chloride; Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis; Association of urinary metal levels with metabolic syndrome in coal workers; TFEB/LAMP2 contributes to PM0.2-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes. Representative work: To explore the epigenetic mechanism of deoxyribonucleic acid (DNA) damage induced by vinyl chloride (VC), we studied the micronuclei of peripheral blood lymphocytes in 193 subjects (92 in a VC exposure group employed in a chlorine-alkali plant; 101 in a control group employed in a power plant) and selected three pairs from the subjects (exposed and control) for whole-genome bisulfite sequencing (WGBS). The results showed that the rate of micronucleus formation in the VC exposure group was higher than that of control group (6.05 ± 3.28‰ vs. 2.01 ± 1.79‰). A total of 9534 differentially methylated regions (DMRs) were identified by WGBS, of which 4816 were hypomethylated and 4718 were hypermeth Abstract Vinyl chloride (VC) is a common industrial organic chlorine and environmental pollutant. In recent years, the dietary structure of residents especially Chinese has gradually shifted to western dietary patterns. VC aggravates dietary fatty acid‐induced hepatic steatosis, but its mechanism is still unclear. And if the risk factors for steatosis persist, more severe diseases such as fibrosis and cirrhosis will occur. Therefore, we studied the effects and mechanisms of VC (160 and 800 mg/m 3 ) and its metabolite (chloroacetaldehyde, 2.25, 4.5, and 9 μM) on hepatic steatosis of high‐fat diet (HFD)‐fed mice and palmitic acid (PA, 100 μM) treated HepG2 cells. Liver and serum biochemical in
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter
Association of urinary metal levels with metabolic syndrome in coal workers
TFEB/LAMP2 contributes to PM0.2-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes
Novel deoxyribonucleic acid methylation perturbations in workers exposed to vinyl chloride
Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis