Area of research
Pathology and Forensic Medicine · Cancer Research
Research interest
Research interests include Genetic factors in colorectal cancer, Cancer Genomics and Diagnostics, BRCA gene mutations in cancer, and Colorectal Cancer Treatments and Studies.
Evaluation of homologous recombination testing in ovarian carcinoma.
Assessing the Detection Power of Genome-Wide Copy Number Variation Profiles in Prostate Cancer Using Simulated Shallow Whole-Genome Sequencing Data.
Molecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study.
Clinical long-read genome sequencing for rare disease diagnostics
Pharmacokinetic boosting of olaparib: Study protocol of a multicentre, open-label, randomised, non-inferiority trial (PROACTIVE-B).
Nationwide implementation and evaluation of the Tumor-First workflow for genetic testing in ovarian carcinoma.
Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.
Exome-based cancer predisposition gene testing can provide a genetic diagnosis for individuals with heterogeneous tumor phenotypes.
Dietary and lifestyle inflammation scores in relation to colon cancer recurrence in subgroups of patients based on common molecular tumour characteristics
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer.
Genomic instability in non-breast or ovarian malignancies of individuals with germline pathogenic variants in BRCA1/2.
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.
A Micro-Costing Framework for Circulating Tumor DNA Testing in Dutch Clinical Practice.
Microsatellite instability in noncolorectal and nonendometrial malignancies in patients with Lynch syndrome.
PARPing up the right tree; an overview of PARP inhibitors for metastatic castration-resistant prostate cancer.
Healthcare professionals' perspectives on implementation of universal tumor DNA testing in ovarian cancer patients: multidisciplinary focus groups.
Genome sequencing as a generic diagnostic strategy for rare disease
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes
Cost-Effectiveness of Parallel Versus Sequential Testing of Genetic Aberrations for Stage IV Non–Small-Cell Lung Cancer in the Netherlands
Impact of DNA damage repair defects on response to PSMA radioligand therapy in metastatic castration-resistant prostate cancer.
Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients.
Cost-Effectiveness of Parallel Versus Sequential Testing of Genetic Aberrations for Stage IV Non-Small-Cell Lung Cancer in the Netherlands.
Circulating Tumor DNA-Based Disease Monitoring of Patients with Locally Advanced Esophageal Cancer.
Identification of Fusion Genes and Targets for Genetically Matched Therapies in a Large Cohort of Salivary Gland Cancer Patients.
Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer.
Correction to: Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer.
European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer