Area of research
Molecular Biology · Environmental Chemistry
Research interest
Research interests include Nicotinic Acetylcholine Receptors Study, Ion channel regulation and function, Receptor Mechanisms and Signaling, and Marine Toxins and Detection Methods.
A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter
Singapore blue arboreal tarantula peptide Lv1a preferentially targets Na<sub>V</sub>1.6 with new world-like pharmacological mechanism.
Inhibition of N-type calcium channels by phenoxyanilide analogues.
Advances in the synthesis and engineering of conotoxins.
High ciguatoxin-producing Gambierdiscus clade (Gonyaulacales, Dinophyceae) as a source of toxins causing ciguatera poisoning.
Reviewing Evidence for Disturbance to Coral Reefs Increasing the Risk of Ciguatera.
Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels
A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests Few <i>Gambierdiscus</i> Species Can Produce Poisonous Herbivores, and Even Fewer Can Produce Poisonous Higher Trophic Level Fish.
Modelling the Bioaccumulation of Ciguatoxins in Parrotfish on the Great Barrier Reef Reveals Why Biomagnification Is Not a Property of Ciguatoxin Food Chains.
PeptideMiner-neuropeptide discovery across the animal kingdom.
Venom Peptides Across Asian and American Tarantulas Utilize Dual Pharmacology to Target Activation and Fast Inactivation of Voltage-Gated Sodium Channels.
Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with <i>In Vivo</i> Zebrafish Larvae Assays.
Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via Ca<sub>V</sub>3.3 and Ca<sub>V</sub>3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain.
HSQC Spectra Simulation and Matching for Molecular Identification.
Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues.
<i>N</i>-Sulfonylphenoxazines as neuronal calcium ion channel blockers.
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail.
Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety.
Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples.
Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.
Model of the Origin of a Ciguatoxic Grouper (<i>Plectropomus leopardus</i>).
The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli.
Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes.
Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors.
Correction to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction".
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
Origin of Ciguateric Fish: Quantitative Modelling of the Flow of Ciguatoxin through a Marine Food Chain.
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAF<sup>V600E</sup>.