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Shirish M. Gadgeel

The Barbara Ann Karmanos Cancer Institute · US
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Area of research
Pulmonary and Respiratory Medicine · Oncology
Research interest
Research interests include Lung Cancer Treatments and Mutations, Lung Cancer Research Studies, Lung Cancer Diagnosis and Treatment, and Cancer Immunotherapy and Biomarkers.
h-index
77
citations
42,327
works
846
NIH funding
primary concept
Medicine
email

Recent publications

Overall Survival with Amivantamab–Lazertinib in <i>EGFR</i> -Mutated Advanced NSCLC
New England Journal of Medicine 2025cited by 70position: middledoi
Practical management of adverse events in patients receiving tarlatamab, a delta‐like ligand 3–targeted bispecific T‐cell engager immunotherapy, for previously treated small cell lung cancer
Cancer 2025cited by 27position: middledoi
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation
Signal Transduction and Targeted Therapy 2025cited by 18position: middledoi
Alectinib versus crizotinib in previously untreated ALK-positive advanced non-small cell lung cancer: final overall survival analysis of the phase III ALEX study
Annals of Oncology 2025cited by 9position: middledoi
LBA64 Safety and performance of a multi-cancer early detection (MCED) test in an intended-use population: Initial results from the registrational PATHFINDER II study
Annals of Oncology 2025cited by 6position: middledoi
Amivantamab plus Lazertinib in Previously Untreated <i>EGFR</i> -Mutated Advanced NSCLC
New England Journal of Medicine 2024cited by 361position: middledoi
Therapy for Stage IV Non–Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2023.3
Journal of Clinical Oncology 2024cited by 80position: middledoi
Therapy for Stage IV Non–Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2023.3
Journal of Clinical Oncology 2024cited by 53position: middledoi
Sustained Clinical Benefit and Intracranial Activity of Tarlatamab in Previously Treated Small Cell Lung Cancer: DeLLphi-300 Trial Update
Journal of Clinical Oncology 2024cited by 44position: middledoi
Pembrolizumab Plus Chemotherapy for Metastatic NSCLC With Programmed Cell Death Ligand 1 Tumor Proportion Score Less Than 1%: Pooled Analysis of Outcomes After Five Years of Follow-Up
Journal of Thoracic Oncology 2024cited by 36position: firstdoi
FURTHER: A global study to evaluate furmonertinib in patients with EGFR mutant NSCLC including uncommon EGFR mutations (FURMO-002).
Journal of Clinical Oncology 2024cited by 5position: middledoi
Proceedings of the 1st biannual bridging the gaps in lung cancer conference
The Oncologist 2024cited by 1position: middledoi
624P Belvarafenib in patients (pts) with BRAF class II or III alteration-positive tumours: TAPISTRY study
Annals of Oncology 2024cited by 1position: middledoi
Pembrolizumab Plus Pemetrexed and Platinum in Nonsquamous Non–Small-Cell Lung Cancer: 5-Year Outcomes From the Phase 3 KEYNOTE-189 Study
Journal of Clinical Oncology 2023cited by 615position: middledoi
SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
Cancer Discovery 2023cited by 65position: middledoi
Selective Personalized RadioImmunotherapy for Locally Advanced Non–Small-Cell Lung Cancer Trial (SPRINT)
Journal of Clinical Oncology 2023cited by 56position: middledoi
MRTX-500 Phase 2 Trial: Sitravatinib With Nivolumab in Patients With Nonsquamous NSCLC Progressing On or After Checkpoint Inhibitor Therapy or Chemotherapy
Journal of Thoracic Oncology 2023cited by 37position: middledoi
Phase II Study of Docetaxel and Trametinib in Patients with <i>KRAS</i> Mutation Positive Recurrent Non–Small Cell Lung Cancer (NSCLC; SWOG S1507, NCT-02642042)
Clinical Cancer Research 2023cited by 19position: firstdoi
Adagrasib in Non–Small-Cell Lung Cancer Harboring a <i> KRAS <sup>G12C</sup> </i> Mutation
New England Journal of Medicine 2022cited by 958position: middledoi
NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations
Cancer Discovery 2022cited by 49position: middledoi
Associations of Tissue Tumor Mutational Burden and Mutational Status With Clinical Outcomes With Pembrolizumab Plus Chemotherapy Versus Chemotherapy For Metastatic NSCLC
JTO Clinical and Research Reports 2022cited by 41position: middledoi
Safety and preliminary clinical activity of NVL-520, a highly selective ROS1 inhibitor, in patients with advanced ROS1 fusion-positive solid tumors
European Journal of Cancer 2022cited by 11position: middledoi
Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study
The Lancet Oncology 2021cited by 441position: middledoi
Pemetrexed plus platinum with or without pembrolizumab in patients with previously untreated metastatic nonsquamous NSCLC: protocol-specified final analysis from KEYNOTE-189
Annals of Oncology 2021cited by 414position: middledoi
Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium
Annals of Oncology 2021cited by 326position: middledoi
Activity and Safety of Mobocertinib (TAK-788) in Previously Treated Non–Small Cell Lung Cancer with <i>EGFR</i> Exon 20 Insertion Mutations from a Phase I/II Trial
Cancer Discovery 2021cited by 222position: middledoi
Comparative clinical outcomes for patients with advanced NSCLC harboring EGFR exon 20 insertion mutations and common EGFR mutations
Lung Cancer 2021cited by 77position: middledoi
Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non–Small-Cell Lung Cancer
Journal of Clinical Oncology 2020cited by 1,146position: firstdoi
Patient-reported outcomes following pembrolizumab or placebo plus pemetrexed and platinum in patients with previously untreated, metastatic, non-squamous non-small-cell lung cancer (KEYNOTE-189): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
The Lancet Oncology 2020cited by 211position: middledoi
Long-Term Overall Survival From KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin With or Without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous NSCLC
Journal of Thoracic Oncology 2020cited by 181position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

D. Ross Camidge · University of Colorado Anschutz Medical Campus15 papers (2013–2025)Lecia V. Sequist · Harvard University14 papers (2013–2024)Hossein Borghaei · The Ohio State University14 papers (2015–2025)Leena Gandhi · Celldex Therapeutics (United States)13 papers (2014–2018)Matthew A. Gubens · UCSF Helen Diller Family Comprehensive Cancer Center12 papers (2015–2024)Amita Patnaik · South Texas Accelerated Research Therapeutics11 papers (2015–2020)Steven Powell · Sanford Health11 papers (2016–2023)James Chih‐Hsin Yang · National Institutes of Health10 papers (2015–2020)Sai‐Hong Ignatius Ou · University of California, Irvine Medical Center10 papers (2014–2022)Corey J. Langer · Pennsylvania Hospital10 papers (2016–2020)Enriqueta Felip · Université Grenoble Alpes10 papers (2015–2024)James Stevenson · Cleveland Clinic10 papers (2015–2020)Edward B. Garon · Cancer Clinic9 papers (2013–2023)M. Catherine Pietanza · Merck & Co., Inc., Rahway, NJ, USA (United States)9 papers (2019–2023)Marina Chiara Garassino · Comprehensive Cardiovascular9 papers (2019–2024)Delvys Rodríguez‐Abreu · Universidad de Las Palmas de Gran Canaria8 papers (2019–2024)Gregory J. Riely · Weill Cornell Medicine7 papers (2014–2022)Alice T. Shaw · Harvard University7 papers (2015–2019)Viola W. Zhu · Covalent Associates (United States)7 papers (2019–2022)Rina Hui · The University of Sydney7 papers (2019–2023)
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