Area of research
Molecular Biology · Endocrinology, Diabetes and Metabolism
Research interest
Research interests include Chromatin Remodeling and Cancer, Thyroid Disorders and Treatments, Mechanisms of cancer metastasis, and Cancer Mechanisms and Therapy.
STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies
Human Type 1 Iodothyronine Deiodinase ( <i>DIO1</i> ) Mutations Cause Abnormal Thyroid Hormone Metabolism
Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by <i>MCT8</i> Gene Mutation
Mice Hypomorphic for <i>Keap1</i> , a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels
Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous <i>SBP2</i> (<i>SECISBP2</i>) Mutations
A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo
TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice
Fetal Exposure to High Maternal Thyroid Hormone Levels Causes Central Resistance to Thyroid Hormone in Adult Humans and Mice
Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency
An Essential Physiological Role for MCT8 in Bone in Male Mice
Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model
Adeno Associated Virus 9–Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice
Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice
A Mouse Model Suggests Two Mechanisms for Thyroid Alterations in Infantile Cystinosis: Decreased Thyroglobulin Synthesis Due to Endoplasmic Reticulum Stress/Unfolded Protein Response and Impaired Lysosomal Processing
Mutations of the Thyroid Hormone Transporter MCT8 Cause Prenatal Brain Damage and Persistent Hypomyelination
Tissue-Specific Posttranslational Modification Allows Functional Targeting of Thyrotropin
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways
Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice
Mct8-Deficient Mice Have Increased Energy Expenditure and Reduced Fat Mass That Is Abrogated by Normalization of Serum T3 Levels
Generation of functional thyroid from embryonic stem cells
Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid
Thyroid Regeneration: Characterization of Clear Cells After Partial Thyroidectomy