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Jessica Alföldi

Broad Institute ·
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Area of research
Genetics · Molecular Biology
Research interest
Research interests include Genomics and Phylogenetic Studies, Genomics and Rare Diseases, Virus-based gene therapy research, and Cancer Genomics and Diagnostics.
h-index
37
citations
24,249
works
98
NIH funding
primary concept
Biology
email

Recent publications

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Nature Communications 2025cited by 10position: middledoi
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature 2024cited by 175position: middledoi
A genomic mutational constraint map using variation in 76,156 human genomes
Nature 2023cited by 1,273position: middledoi
Inferring compound heterozygosity from large-scale exome sequencing data
Nature Genetics 2023cited by 34position: middledoi
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans
Nature 2021cited by 61position: middledoi
Author Correction: A structural variation reference for medical and population genetics
Nature 2021cited by 17position: middledoi
The mutational constraint spectrum quantified from variation in 141,456 humans
Nature 2020cited by 10,012position: middledoi
Progressive Cactus is a multiple-genome aligner for the thousand-genome era
Nature 2020cited by 637position: middledoi
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer
Cancer Cell 2020cited by 324position: middledoi
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals
Nature Communications 2020cited by 191position: middledoi
Evaluating drug targets through human loss-of-function genetic variation
Figshare 2020cited by 163position: middle
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Nature Communications 2020cited by 143position: middledoi
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals
Proceedings of the National Academy of Sciences 2019cited by 71position: middledoi
A comprehensive genomic history of extinct and living elephants
Proceedings of the National Academy of Sciences 2018cited by 211position: middledoi
Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
Proceedings of the National Academy of Sciences 2017cited by 118position: middledoi
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Nature Genetics 2016cited by 666position: middledoi
FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome
Nucleic Acids Research 2016cited by 475position: middledoi
Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
HAL (Le Centre pour la Communication Scientifique Directe) 2016cited by 1position: middle
Convergent evolution of the genomes of marine mammals
Nature Genetics 2015cited by 495position: middledoi
The genomic substrate for adaptive radiation in African cichlid fish
Nature 2014cited by 1,048position: middledoi
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
Nature 2014cited by 667position: middledoi
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
Science 2014cited by 425position: middledoi
Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes
Cell 2014cited by 355position: middledoi
An Improved Canine Genome and a Comprehensive Catalogue of Coding Genes and Non-Coding Transcripts
PLoS ONE 2014cited by 310position: middledoi
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease
Nature Biotechnology 2014cited by 147position: middledoi
The African coelacanth genome provides insights into tetrapod evolution
Nature 2013cited by 690position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Kerstin Lindblad‐Toh · Broad Institute3 papers (2015–2020)Jeremy Johnson · University of South Alabama2 papers (2016–2020)Kim C. Worley · Baylor College of Medicine1 papers (2015–2015)Shaohong Feng · Shanghai Liangyou (China)1 papers (2020–2020)Erich D. Jarvis · Rockefeller University1 papers (2020–2020)Tosso Leeb · University of Bern1 papers (2016–2016)Alden Deran · University of California, Santa Cruz1 papers (2020–2020)Adam M. Novak · SUNY Upstate Medical University1 papers (2020–2020)Josefin Stiller · University of Copenhagen1 papers (2020–2020)Eric Vallabh Minikel · Broad Institute1 papers (2020–2020)Jacob L. Mueller · University of Michigan–Ann Arbor1 papers (2014–2014) · 1 papers (2014–2014)Margaret E. Hunter · University of Florida1 papers (2015–2015)Richard C. Trembath · King's College London1 papers (2020–2020)Duo Xie · Nanjing Institute of Astronomical Optics & Technology1 papers (2020–2020)Donna M. Muzny · Baylor College of Medicine1 papers (2015–2015)Matthew W. Hahn · European Bioinformatics Institute1 papers (2015–2015) · 1 papers (2016–2016)Benoît Hédan · Centre National de la Recherche Scientifique1 papers (2016–2016)Voichita D. Marinescu · Science for Life Laboratory1 papers (2020–2020)
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