Area of research
Cellular and Molecular Neuroscience · Molecular Biology
Research interest
Research interests include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Amyotrophic Lateral Sclerosis Research, and RNA Research and Splicing.
A Trial of an Antibody–Oligonucleotide Conjugate
Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice
PERK Deficiency Amplifies Molecular, Structural, and Network Vulnerability to Repetitive Mild Traumatic Brain Injury
<i>CASP8</i> intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk
PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice
Staufen Impairs Autophagy in Neurodegeneration
CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity
RAN proteins in neurodegenerative disease: Repeating themes and unifying therapeutic strategies
Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia
Intron retention induced by microsatellite expansions as a disease biomarker
Mutant Huntingtin Disrupts the Nuclear Pore Complex
RAN Translation in Huntington Disease
RAN proteins and RNA foci from antisense transcripts in <i>C9ORF72</i> ALS and frontotemporal dementia