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Neil A. O’Brien

APLA Health ·
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Area of research
Radiology, Nuclear Medicine and Imaging · Oncology
Research interest
Research interests include HER2/EGFR in Cancer Research, Monoclonal and Polyclonal Antibodies Research, Advanced Breast Cancer Therapies, and Lung Cancer Treatments and Mutations.
h-index
27
citations
2,289
works
373
NIH funding
primary concept
email

Recent publications

Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
Clinical Cancer Research 2023cited by 48position: middledoi
Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses
Cancer Immunology Research 2023cited by 32position: middledoi
Targeting CDK4 and 6 in Cancer Therapy: Emerging Preclinical Insights Related to Abemaciclib
The Oncologist 2022cited by 37position: middledoi
Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer
Breast Cancer Research 2020cited by 155position: firstdoi
Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer
Molecular Cancer Therapeutics 2018cited by 107position: firstdoi
Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells
International Journal of Oncology 2017cited by 41position: middledoi
In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response
Breast Cancer Research and Treatment 2015cited by 64position: middledoi
Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Clinical Cancer Research 2014cited by 117position: firstdoi
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance
Oncogene 2014cited by 56position: middledoi
Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer
Oncotarget 2013cited by 164position: middledoi
Activity of the Fibroblast Growth Factor Receptor Inhibitors Dovitinib (TKI258) and NVP-BGJ398 in Human Endometrial Cancer Cells
Molecular Cancer Therapeutics 2013cited by 73position: middledoi
Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer
Molecular Cancer Therapeutics 2013cited by 68position: middledoi
Current approaches and future directions in the treatment of HER2-positive breast cancer
Cancer Treatment Reviews 2012cited by 148position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Dennis J. Slamon · APLA Health9 papers (2013–2023)Richard S. Finn · United States Olympic & Paralympic Committee6 papers (2012–2015)Dylan Conklin · APLA Health5 papers (2013–2020)Sara A. Hurvitz · University of Washington Applied Physics Laboratory5 papers (2012–2020)Ondrej Kalous · University of California, Los Angeles4 papers (2013–2018)Raul Ayala · University of California, Los Angeles3 papers (2013–2020)Ronald Linnartz · Novartis (Switzerland)3 papers (2014–2020)Kevin Chau · University of California, Los Angeles3 papers (2018–2023)Tong Luo · Army Medical University3 papers (2014–2020)Martina S.J. McDermott · University of California, Los Angeles3 papers (2017–2023)Samit Hirawat · Ludwig-Maximilians-Universität München2 papers (2014–2020)John Crown · Lublin Oncology Center2 papers (2013–2017)Erika von Euw · University of Wisconsin–Madison2 papers (2014–2018)Teodora Kolarova · University of Washington2 papers (2013–2015)Lee Anderson · Broad Institute2 papers (2013–2015)Alexandra Canonici · Royal College of Surgeons in Ireland2 papers (2013–2017)Amrita Desai · Oregon Health & Science University2 papers (2013–2015)Tong Luo · Guangzhou University of Chinese Medicine2 papers (2013–2023)Norma O’Donovan · Royal College of Surgeons in Ireland2 papers (2013–2017)Glenn Dranoff · Dana-Farber Cancer Institute1 papers (2023–2023)
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