Area of research
Molecular Biology · Gastroenterology
Research interest
Research interests include Gastrointestinal motility and disorders, Ion channel regulation and function, Ion Channels and Receptors, and Cardiac electrophysiology and arrhythmias.
Interstitial cells of Cajal - pacemakers of the gastrointestinal tract.
Role of interstitial cells of Cajal in regulating tone and responses to enteric motor neurons in the murine pyloric sphincter.
Disruption of gastrointestinal PDGFRα<sup>+</sup> cells leads to loss of postjunctional inhibitory motor responses.
International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.
International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease
Functional roles of interstitial cells of Cajal in the GI tract of rats.
A specialized population of intramuscular interstitial cells of Cajal regulates motility within the mouse oesophagogastric junction.
Secretin targets interstitial cells of Cajal to regulate intestinal contractions.
Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.
Ca<sup>2+</sup> dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract.
Integrated responses of the SIP syncytium generate a major motility pattern in the colon.
Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.
miR‐10b‐5p rescues leaky gut linked with gastrointestinal dysmotility and diabetes
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle.
Cardiac PDGFRα<sup>+</sup> interstitial cells generate spontaneous inward currents that contribute to excitability in the heart.
Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.
Ca<sup>2+</sup> signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters.
Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner.
Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.
Distinguishing the contributions of neuronal and mucosal serotonin in the regulation of colonic motility.
Characterization of the A-type potassium current in murine gastric fundus smooth muscles.
Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon.
Identification and classification of interstitial cells in the mouse renal pelvis.
Extracellular metabolism of the enteric inhibitory neurotransmitter β-nicotinamide adenine dinucleotide (β-NAD) in the murine colon.
Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract.
Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility
Ca<sup>2+</sup> signalling behaviours of intramuscular interstitial cells of Cajal in the murine colon.
An ex vivo bladder model with detrusor smooth muscle removed to analyse biologically active mediators released from the suburothelium.
Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility.
The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach