Area of research
Renewable Energy, Sustainability and the Environment · Pharmacology
Research interest
Research topics from publications: Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases. Representative work: BACKGROUND & AIMS: Sleep disorders (SDs) are common in chronic liver diseases (CLDs). Some SDs arise from impaired internal clock and are, hence, circadian rhythm SDs (CRSDs). Bile acids (BAs), whose levels are increased in many CLDs, reciprocally interact with circadian rhythm. This study explores the mechanisms underlying CRSDs in CLDs and novel therapies. METHODS: We monitored the sleep of patients with CLD using actigraphic watch and established male mouse cholemia models by feeding with BA or bile duct ligation. Sleep-wake cycle and circadian rhythm were analyzed by electroencephalogram-electromyography and locomotor wheel-running experiments. RESULTS: Patients with CLD showed CRSD-like