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Mark A. Frye

Salk Institute for Biological Studies ·
Area of research
Psychiatry and Mental health · Pharmacology
Research interest
Research interests include Bipolar disorder, Medicine, Internal medicine, Psychiatry, Genome-wide association study, and Lithium (medication).
h-index
citations
5,874
works
68
NIH funding
primary concept
email

Recent publications

Fine-mapping genomic loci refines bipolar disorder risk genes
Nature Neuroscience 2025cited by 20position: middledoi
New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways
Biological Psychiatry 2025cited by 8position: middledoi
Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder
Biological Psychiatry Global Open Science 2025cited by 6position: middledoi
Utilizing depression symptom-based phenotypes to explore ketamine treatment response in major depression: The Bio-K multicenter trial
Journal of Affective Disorders 2025cited by 4position: middledoi
A Critical Role of Philanthropic Support in Paving the Way to Precision Medicine for Bipolar Disorder
Biological Psychiatry 2025cited by 1position: middledoi
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder
Translational Psychiatry 2024cited by 13position: middledoi
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Nature Mental Health 2023cited by 223position: middledoi
Patterns of pharmacotherapy for bipolar disorder: A <scp>GBC</scp> survey
Bipolar Disorders 2023cited by 74position: middledoi
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Molecular Psychiatry 2023cited by 39position: middledoi
Prevalence and outcomes of rapid cycling bipolar disorder: Mixed method systematic meta-review
Journal of Psychiatric Research 2023cited by 30position: middledoi
Insulin resistance in bipolar disorder: A systematic review of illness course and clinical correlates
Journal of Affective Disorders 2023cited by 29position: middledoi
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
Molecular Psychiatry 2023cited by 27position: middledoi
The Association Between Thyroid Stimulating Hormone and Depression
Mayo Clinic Proceedings 2023cited by 24position: middledoi
Supercharging collaboration for bipolar research—Breakthrough discoveries for thriving with bipolar disorder (<scp>BD<sup>2</sup></scp>)
Bipolar Disorders 2023cited by 5position: middledoi
Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression
Biological Psychiatry 2023cited by 0position: middledoi
Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression
Biological Psychiatry 2023cited by 0position: middledoi
The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
World Psychiatry 2022cited by 151position: middledoi
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative
Bipolar Disorders 2022cited by 59position: middledoi
The Modernization of Clozapine
Journal of Clinical Psychopharmacology 2022cited by 41position: middledoi
Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach
The British Journal of Psychiatry 2022cited by 40position: middledoi
Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder
Bipolar Disorders 2022cited by 29position: middledoi
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
Molecular Psychiatry 2022cited by 22position: lastdoi
Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies
Journal of Affective Disorders 2022cited by 21position: lastdoi
The genetics of bipolar disorder with obesity and type 2 diabetes
Journal of Affective Disorders 2022cited by 21position: middledoi
Clinician Satisfaction with Rapid Adoption and Implementation of Telehealth Services During the COVID-19 Pandemic
Telemedicine Journal and e-Health 2021cited by 98position: middledoi
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression
Translational Psychiatry 2021cited by 96position: middledoi
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Translational Psychiatry 2021cited by 59position: middledoi
Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies
Molecular Psychiatry 2021cited by 51position: middledoi
Characterisation of age and polarity at onset in bipolar disorder
The British Journal of Psychiatry 2021cited by 50position: middledoi
Clinical predictors of non‐response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study
Bipolar Disorders 2021cited by 37position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Joanna M. Biernacka · Mayo Clinic15 papers (2014–2023)Richard M. Weinshilboum · University of Oslo11 papers (2014–2020)William V. Bobo · University of Iowa8 papers (2016–2025)Susan L. McElroy · Southwestern Medical Center8 papers (2014–2023)Balwinder Singh · Pacific Northwest National Laboratory7 papers (2022–2025)Rima Kaddurah‐Daouk · Duke University7 papers (2016–2020) · 6 papers (2014–2019)Liewei Wang · Mayo Clinic6 papers (2018–2020) · 6 papers (2016–2020)Marin Veldić · University of Illinois Chicago6 papers (2022–2023)Boadie W. Dunlop · Emory University5 papers (2018–2020) · 5 papers (2022–2023)Duan Liu · Southern Medical University5 papers (2016–2020)Alessandro Miola · University of Padua5 papers (2022–2023)A. John Rush · Texas Tech University5 papers (2018–2019) · 5 papers (2017–2023) · 4 papers (2014–2018) · 4 papers (2022–2023) · 4 papers (2022–2023)Gregory D. Jenkins · WinnMed4 papers (2014–2018)