Area of research
Immunology · Epidemiology
Research interest
Research interests include T-cell and B-cell Immunology, Immune Cell Function and Interaction, Diabetes and associated disorders, and Influenza Virus Research Studies.
Adipocyte‐derived inflammatory molecules induce senescent B cells through metabolic pathways
Obesity accelerates age defects in B cells, and weight loss improves B cell function
Obesity Accelerates Age-Associated Defects in Human B Cells Through a Metabolic Reprogramming Induced by the Fatty Acid Palmitate
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
Phenotypic and Functional Characterization of Double Negative B Cells in the Blood of Individuals With Obesity
The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing
B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus
Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities
Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity
Metabolic requirements of human pro-inflammatory B cells in aging and obesity
Leptin induces immunosenescence in human B cells
Secretion of autoimmune antibodies in the human subcutaneous adipose tissue
Obesity induces pro-inflammatory B cells and impairs B cell function in old mice
Metformin improves in vivo and in vitro B cell function in individuals with obesity and Type-2 Diabetes
Aging effects on T-bet expression in human B cell subsets
Obesity decreases <scp>B</scp> cell responses in young and elderly individuals
Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways
The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations
Ageing and obesity similarly impair antibody responses
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals
High TNF-α levels in resting B cells negatively correlate with their response
Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine
Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season
Immune response to influenza A/H1N1 vaccine in inflammatory bowel disease patients treated with anti TNF-α agents: Effects of combined therapy with immunosuppressants
Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine