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James C. Lee

Illinois College · US
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Area of research
Physiology · Neurology
Research interest
Research interests include Alzheimer's disease research and treatments, Neuroinflammation and Neurodegeneration Mechanisms, Fatty Acid Research and Health, and Lipid Membrane Structure and Behavior.
h-index
29
citations
5,853
works
58
NIH funding
primary concept
email

Recent publications

Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions
Arteriosclerosis Thrombosis and Vascular Biology 2025cited by 3position: middledoi
The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation
Pharmacogenetics and Genomics 2024cited by 18position: middledoi
Oligomeric Tau-induced oxidative damage and functional alterations in cerebral endothelial cells: Role of RhoA/ROCK signaling pathway
Free Radical Biology and Medicine 2024cited by 14position: lastdoi
Oligomeric Amyloid-β and Tau Alter Cell Adhesion Properties and Induce Inflammatory Responses in Cerebral Endothelial Cells Through the RhoA/ROCK Pathway
Molecular Neurobiology 2024cited by 11position: lastdoi
Caveolin-1 is a primary determinant of endothelial stiffening associated with dyslipidemia, disturbed flow, and ageing
Scientific Reports 2022cited by 28position: middledoi
Neuroprotective effects of DHA-derived peroxidation product 4(RS)-4-F4t-neuroprostane on microglia
Free Radical Biology and Medicine 2022cited by 21position: lastdoi
Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing
Genetics in Medicine 2021cited by 69position: middledoi
Cell–Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells
ACS Nano 2021cited by 59position: middledoi
Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System
Cells 2021cited by 58position: lastdoi
Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues
Nature Biomedical Engineering 2021cited by 45position: middledoi
Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro
Frontiers in Cell and Developmental Biology 2021cited by 34position: middledoi
Meta-analysis comparing direct oral anticoagulants versus vitamin K antagonists in patients with left ventricular thrombus
PLoS ONE 2021cited by 24position: middledoi
Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx
American Journal of Physiology-Heart and Circulatory Physiology 2021cited by 22position: middledoi
Impact of the <i>CYP2C19*17</i> Allele on Outcomes in Patients Receiving Genotype‐Guided Antiplatelet Therapy After Percutaneous Coronary Intervention
Clinical Pharmacology & Therapeutics 2020cited by 49position: middledoi
Impairment of Flow-Sensitive Inwardly Rectifying K <sup>+</sup> Channels via Disruption of Glycocalyx Mediates Obesity-Induced Endothelial Dysfunction
Arteriosclerosis Thrombosis and Vascular Biology 2020cited by 49position: middledoi
Potential Implications of Gut Microbiota in Drug Pharmacokinetics and Bioavailability
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy 2020cited by 35position: lastdoi
Controlled Deposition of 3D Matrices to Direct Single Cell Functions
Advanced Science 2020cited by 30position: middledoi
Roles of microglial membranes in Alzheimer's disease
Current topics in membranes 2020cited by 8position: lastdoi
Precision pharmacotherapy: Integrating pharmacogenomics into clinical pharmacy practice
JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 2019cited by 82position: lastdoi
Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System
Frontiers in Neurology 2019cited by 68position: middledoi
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing
Genetics in Medicine 2019cited by 67position: middledoi
Use of Direct Oral Anticoagulants in Morbidly Obese Patients
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy 2019cited by 37position: middledoi
Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia
Molecular Neurobiology 2019cited by 30position: lastdoi
Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells
International Journal of Molecular Sciences 2019cited by 26position: middledoi
Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice
Metabolites 2019cited by 20position: middledoi
PRN OPINION PAPER: Application of precision medicine across pharmacy specialty areas
JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 2019cited by 15position: middledoi
Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
Journal of Neuroinflammation 2018cited by 64position: middledoi
Azelnidipine Attenuates the Oxidative and NFκB Pathways in Amyloid-β-Stimulated Cerebral Endothelial Cells
ACS Chemical Neuroscience 2018cited by 14position: lastdoi
Cytosolic Phospholipase A2 Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity
Molecular Neurobiology 2018cited by 13position: lastdoi
Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Prostaglandins Leukotrienes and Essential Fatty Acids 2017cited by 302position: middledoi

Grants

AF: Small: Metric Information Theory, Online Learning, and Competitive Analysis
NSF2007079$400,0002020–2023PIRePORTER
AF: Small: Entropy Maximization in Approximation, Learning, and Complexity
NSF1616297$466,0002016–2020PIRePORTER
AF: Medium: Collaborative Research: On the Power of Mathematical Programming in Combinatorial Optimization
NSF1407779$367,4302014–2018PIRePORTER
AF: Small: Metric Geometry for Combinatorial Problems
NSF1217256$399,9842012–2015PIRePORTER
A Renewal Proposal for the Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices
NSF0914790$13,078,7432009–2015PIRePORTER
AF: Small: Spectral analysis, spectral algorithms, and beyond
NSF0915251$500,0002009–2013PIRePORTER
CAREER: Geometric Phenomena in Algorithms and Complexity
NSF0644037$400,0002007–2012PIRePORTER
Travel Grant to Present the Proposal Writing Tutorial for the NSF Workshop at the AIChE Annual Meeting in Salt Lake City, Utah
NSF0801375$4,8892007–2009PIRePORTER
PostDoctoral Research Fellowship in the Mathematical Sciences
NSF0503356$02005–2009PIRePORTER
NSEC: Center for Affordable Nanoengineering of Polymer Biomedical Devices (CANPBD)
NSF0425626$13,183,9602004–2011PIRePORTER
NIRT: Robust Manufacturing Protocol for Particulate-like Nanoporous Micro-devices (NMDs) for Biomedical and Biochemical Applications (Manufacturing Processes at the Nanoscale)
NSF0304112$860,0002003–2008PIRePORTER
From Atoms to Continuum: A Multi-scale Multi-Phenomena Theory
NSF0301539$242,4202003–2006PIRePORTER
A Theoretical and Computational Basis for Micro-Continuum Field Theories: From Atomic Model to Continuum Theory
NSF0115868$70,0002002–2003PIRePORTER
NER: Development of a Nano-lithography Based Manufacturing Protocol for Polymer Nanofluidic Platforms
NSF0102639$100,0002001–2003PIRePORTER
GOALI: Development of Advanced Molding Technology for Polymer Micro-/Nano-Fabrication
NSF0084919$396,7662000–2004PIRePORTER
Optimized Production and Stabilization of Mammalian Proteins Secreted from Transgenic Plant Suspension Cultures
NSF9808021$421,2131998–2001PIRePORTER
Supercritical Fluid Enhanced Polymer and Composite Extrusion
NSF9815677$200,0061998–2001PIRePORTER
An Operating Center Proposal for Establishing an I/UCR Center for Advanced Polymer and Composite Engineering
NSF9726048$480,0001997–2003PIRePORTER
Improvement and Optimization of a Newly Developed Vacuum Infusion Resin Transfer Molding Process (SCRIMP)
NSF9616456$343,5271997–2001PIRePORTER
Workshop on the Solution Interactions of Macromolecules to be Held at the University of Texas Medical Branch, Galveston, TX, November 14-16, 1997
NSF9725105$28,0001997–1999PIRePORTER
A Planning Proposal for Establishing an I/UCR Center for Advanced Polymer Engineering
NSF9612323$10,0001996–1997PIRePORTER
Workshop on Manufacturing Polymer Composites by Liquid Molding; Columbus, OH; June 13-14, 1996
NSF9613937$5,0001996–1997PIRePORTER

Frequent collaborators

Grace Y. Sun · University of Missouri12 papers (2017–2024)Xue Geng · Beijing Institute of Technology7 papers (2019–2024)C. Michael Greenlief · University of Missouri7 papers (2017–2021)Bo Yang · University of Missouri6 papers (2018–2021)Kevin L. Fritsche · University of Missouri5 papers (2017–2019)David Q. Beversdorf · University of Missouri5 papers (2017–2019)Tao Teng · University of Illinois Chicago5 papers (2017–2021)Elizabeth Le Master · University of Illinois Urbana-Champaign4 papers (2020–2025)Irena Levitan · University of Illinois Chicago4 papers (2020–2025)Jae‐Won Shin · Seoul National University4 papers (2020–2021)Runting Li · University of Missouri4 papers (2017–2019)Sang Joon Ahn · University of Illinois Chicago4 papers (2020–2025)Zezong Gu · China Pharmaceutical University4 papers (2017–2019)Raymond Bargi · University of Illinois Chicago3 papers (2020–2021)Sing Wan Wong · University of Illinois Chicago3 papers (2020–2021)Kazuhiko Kido · West Virginia University Hospitals2 papers (2019–2021)Víctor Aguilar · University of Illinois Chicago2 papers (2022–2025)Christina L. Aquilante · University of Colorado Denver2 papers (2019–2021)Julio D. Duarte · University of Illinois Chicago2 papers (2020–2021)Dana Lazarko · University of Illinois Chicago2 papers (2022–2025)
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