Area of research
Molecular Biology · Neurology
Research interest
Research interests include Parkinson's Disease Mechanisms and Treatments, 14-3-3 protein interactions, Ubiquitin and proteasome pathways, and Cellular transport and secretion.
Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons
14-3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity
Predictive models for ataxia progression and conversion in spinocerebellar ataxia type 1 and 3
Connectomic-guided stereotactic radiosurgery thalamotomy for tremor: a patient-specific approach to enhance outcomes
The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation
14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity and toxicity
Brain and Systemic Inflammation in De Novo Parkinson's Disease
Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy
The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method
14-3-3 Proteins: Novel Pharmacological Targets in Neurodegenerative Diseases
Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins
Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein
Dysregulation of 14‐3‐3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins
14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson’s disease
LRRK2 secretion in exosomes is regulated by 14-3-3
Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice
α-Synuclein Overexpression Represses 14-3-3θ Transcription
Functional Analysis of VPS41-Mediated Neuroprotection in<i>Caenorhabditis elegans</i>and Mammalian Models of Parkinson's Disease