Area of research
Cellular and Molecular Neuroscience · Neurology
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Neuroscience and Neuropharmacology Research, Neurotransmitter Receptor Influence on Behavior, and Neurogenesis and neuroplasticity mechanisms.
Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder.
Adolescent Binge Ethanol Exposure Confers Lasting Adult Alcohol Tolerance due to Neuroimmune Activation: Reversal by Inhibition of HMGB1.
Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder
Alcohol, HMGB1, and Innate Immune Signaling in the Brain.
In memoriam – George R. Breese, Ph.D
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood.
HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype.
Indomethacin restores loss of hippocampal neurogenesis and cholinergic innervation and reduces innate immune expression and reversal learning deficits in adult male and female rats following adolescent ethanol exposure.
HMGB1 Neuroimmune Signaling and REST-G9a Gene Repression Contribute to Ethanol-induced Reversible Suppression of the Cholinergic Neuron Phenotype
Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood.
Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood
Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder.
TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration.
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder.
Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats
Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise.
Adolescent Alcohol Exposure Produces Protracted Cognitive-Behavioral Impairments in Adult Male and Female Rats.
Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings
Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings.
Neuroimmune and epigenetic involvement in adolescent binge ethanol‐induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise
Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil.
The Toll-Like Receptor 3 Agonist Poly(I:C) Induces Rapid and Lasting Changes in Gene Expression Related to Glutamatergic Function and Increases Ethanol Self-Administration in Rats.
Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling.
Ethanol Induction of Innate Immune Signals Across BV2 Microglia and SH-SY5Y Neuroblastoma Involves Induction of IL-4 and IL-13.
The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood
Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex
Adolescent Intermittent Ethanol Exposure Is Associated with Increased Risky Choice and Decreased Dopaminergic and Cholinergic Neuron Markers in Adult Rats
High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence