Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include RNA Research and Splicing, Genomics and Chromatin Dynamics, RNA and protein synthesis mechanisms, and Prostate Cancer Treatment and Research.
Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct
Using quantitative reconstitution to investigate multicomponent condensates
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN–FOS at composite DNA sites
Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5
ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain
Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination
Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor