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Zachary D. Smith

Yale Cancer Center · US
Area of research
Molecular Biology
Research interest
Research interests include Epigenetics and DNA Methylation, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, and Pluripotent Stem Cells Research.
h-index
39
citations
19,108
works
127
NIH funding
primary concept
email

Recent publications

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis
bioRxiv (Cold Spring Harbor Laboratory) 2026cited by 1position: middledoi
Dynamic antagonism between key repressive pathways maintains the placental epigenome
Nature Cell Biology 2023cited by 23position: middledoi
Hijacking of transcriptional condensates by endogenous retroviruses
Nature Genetics 2022cited by 81position: middledoi
Smart-RRBS for single-cell methylome and transcriptome analysis
Nature Protocols 2021cited by 57position: middledoi
Molecular recording of mammalian embryogenesis
Nature 2019cited by 376position: middledoi
Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance
Scientific Reports 2017cited by 74position: middledoi
Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance
bioRxiv (Cold Spring Harbor Laboratory) 2017cited by 7position: middledoi
Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells
Cell Reports 2016cited by 17position: middledoi
Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency
Cell 2015cited by 248position: middledoi
DNA methylation dynamics of the human preimplantation embryo
Nature 2014cited by 583position: firstdoi
DNA methylation: roles in mammalian development
Nature Reviews Genetics 2013cited by 3,090position: firstdoi
Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
Cell stem cell 2013cited by 480position: middledoi
Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
Cell stem cell 2013cited by 362position: middledoi
A unique regulatory phase of DNA methylation in the early mammalian embryo
Nature 2012cited by 978position: firstdoi
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
Molecular Cell 2012cited by 410position: middledoi
Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling
Genome biology 2012cited by 274position: middledoi
Mouse ooplasm confers context-specific reprogramming capacity
Nature Genetics 2012cited by 68position: middledoi

Grants

CAREER: Systematic Design of Polymers to Reveal the Anomalous Role of Fluorine on Membrane-based Separations
NSF2146422$550,0002022–2027PIRePORTER
Collaborative Research: Crossing the percolation threshold for selective gas transport using interconnected crystals of metal–organic frameworks in polymer-based hybrid membranes
NSF2034742$260,0022021–2025PIRePORTER
I-Corps: Portable Light Scattering Device for Field Diagnosis of Microcytic Anemia
NSF1522627$50,0002015–2015PIRePORTER

Frequent collaborators

Alexander Meissner · Max Planck Institute for Molecular Genetics14 papers (2012–2023)Hongcang Gu · University of Oklahoma Health Sciences Center5 papers (2012–2021) · 4 papers (2012–2021)Michelle M. Chan · Research Network (United States)4 papers (2012–2019) · 3 papers (2019–2023)Aviv Regev · Moscow Institute of Thermal Technology3 papers (2012–2014)Abhishek Sampath Kumar · National University of Singapore2 papers (2022–2023)Rahul Karnik · Harvard Stem Cell Institute2 papers (2014–2015)David Meierhofer · Max Planck Institute for Molecular Genetics2 papers (2022–2023)Chris Renfrow · University of Idaho2 papers (2017–2017)Christoph Bock · I.R.C.C.S. Oasi Maria SS2 papers (2012–2013)Tarjei S. Mikkelsen · Arsenal Biosciences (United States)2 papers (2012–2015) · 2 papers (2022–2023) · 2 papers (2022–2026)Sara Hetzel · Freie Universität Berlin2 papers (2022–2023)Linda Rogers · University of Idaho2 papers (2017–2017)Thibault Stalder · University of Idaho2 papers (2017–2017)Derrick J. Rossi · Harvard Stem Cell Institute2 papers (2012–2013)Michael J. Ziller · Harvard Stem Cell Institute2 papers (2012–2015)Hirokazu Yano · University of Idaho2 papers (2017–2017)