Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Pharmacological Receptor Mechanisms and Effects, and Computational Drug Discovery Methods.
Phosphorylation site topology governs the functional dynamics of arrestin recruitment to GPCRs
Structure-guided design of partial agonists at an opioid receptor
Structure-guided design of partial agonists at an opioid receptor.
Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
Exceptionally Potent Chiral Anandamide Analogs.
Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes.
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1.
Cryo-EM structure of the prostaglandin D2 receptor 1 (DP1) complex in inactive and active states
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target.
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.
Constitutive activation mechanism of a class C GPCR.
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site.
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2.
Scalable computation of anisotropic vibrations for large macromolecular assemblies.
Structure-Guided Design of Partial Agonists at an Opioid Receptor
Computational approaches streamlining drug discovery
Computational approaches streamlining drug discovery.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Molecular mechanism of biased signaling at the kappa opioid receptor.
Ligand and G-protein selectivity in the κ-opioid receptor.
Pharmacological Mechanism of the Non-hallucinogenic 5-HT<sub>2A</sub> Agonist Ariadne and Analogs.
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells.
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D<sub>3</sub> (D<sub>3</sub>R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.
Scalable anisotropic vibrations of megascale macromolecules
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
Structural basis of GABA reuptake inhibition.