Area of research
Molecular Biology · Oncology
Research interest
Research interests include DNA Repair Mechanisms, CRISPR and Genetic Engineering, PARP inhibition in cancer therapy, and Adipokines, Inflammation, and Metabolic Diseases.
Dysregulation of the low-level replication stress response in transformed cell lines.
RAD51-mediated homologous recombination is a pro-tumour driver pathway.
Specific Low/Endogenous Replication Stress Response Protects Genomic Stability via Controlled ROS Production in an Adaptive Way and Is Dysregulated in Transformed Cells.
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1.
Dysregulation of replication stress-induced ROS in transformed cell lines: a vicious circle at cancer initiation
Competition Between Protein and DNA for Binding to Natural Sepiolite Nanofibers.
The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination.
Plot twist: homologous recombination actually promotes the development of cancer!
Human RAD52 stimulates the RAD51-mediated homology search.
PKA prevents resection of DNA double strand breaks and favor non-homologous end-joining
The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination
Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
Noncanonical Roles of RAD51.
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner.
In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis.
Impact of Increased Sonication-Induced Dispersion of Sepiolite on Its Interaction with Biological Macromolecules and Toxicity/Proliferation in Human Cells.
[Controlled production of reactive oxygen species in response to DNA replication stress protects genome stability].
RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function.
<i>In vivo</i> inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Homologous recombination, cancer and the 'RAD51 paradox'.
C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19
Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ.
Mouse Models for Deciphering the Impact of Homologous Recombination on Tumorigenesis.
Binding of DNA to Natural Sepiolite: Applications in Biotechnology and Perspectives
Macrophages in Ischemic Heart Failure: Yesterday, Today, and Tomorrow
Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response.