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Mike Heilemann

Goethe University Frankfurt · DE
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Area of research
Biophysics · Structural Biology
Research interest
Research interests include Advanced Fluorescence Microscopy Techniques, Advanced Electron Microscopy Techniques and Applications, Cell Image Analysis Techniques, and Advanced Biosensing Techniques and Applications.
h-index
68
citations
17,934
works
356
NIH funding
primary concept
email

Recent publications

Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckle–paraspeckle crosstalk during cellular stress
Nucleic Acids Research 2025cited by 5position: middledoi
Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A
Antiviral Research 2024cited by 16position: middledoi
Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum
Nature 2023cited by 159position: middledoi
Exchangeable HaloTag Ligands for Super-Resolution Fluorescence Microscopy
Journal of the American Chemical Society 2023cited by 143position: middledoi
A framework for evaluating the performance of SMLM cluster analysis algorithms
Nature Methods 2023cited by 64position: middledoi
DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches
Communications Biology 2022cited by 110position: middledoi
Unbiased choice of global clustering parameters for single-molecule localization microscopy
Scientific Reports 2022cited by 10position: middledoi
Democratising deep learning for microscopy with ZeroCostDL4Mic
Nature Communications 2021cited by 552position: middledoi
The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
Science Advances 2021cited by 104position: middledoi
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53
Oncogene 2021cited by 40position: middledoi
Universal quenching of common fluorescent probes by water and alcohols
Chemical Science 2020cited by 283position: middledoi
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors
Nature Chemical Biology 2020cited by 128position: middledoi
Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues
Nature Communications 2020cited by 110position: middledoi
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells
Science Signaling 2020cited by 102position: lastdoi
Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia
Leukemia 2020cited by 36position: middledoi
CRISPR/Cas12a-mediated labeling of MET receptor enables quantitative single-molecule imaging of endogenous protein organization and dynamics
iScience 2020cited by 27position: lastdoi
Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling
Journal of Leukocyte Biology 2020cited by 25position: middledoi
Visualizing ubiquitination in mammalian cells
EMBO Reports 2019cited by 126position: lastdoi
Whole-Cell, 3D, and Multicolor STED Imaging with Exchangeable Fluorophores
Nano Letters 2018cited by 156position: lastdoi
A toolbox for multiplexed super-resolution imaging of the E. coli nucleoid and membrane using novel PAINT labels
Scientific Reports 2018cited by 107position: lastdoi
STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles
Proceedings of the National Academy of Sciences 2018cited by 81position: middledoi
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
npj Systems Biology and Applications 2018cited by 22position: middledoi
The Pearling Transition Provides Evidence of Force-Driven Endosomal Tubulation during <i>Salmonella</i> Infection
mBio 2018cited by 19position: middledoi
CD95 receptor activation by ligand-induced trimerization is independent of its partial pre-ligand assembly
bioRxiv (Cold Spring Harbor Laboratory) 2018cited by 6position: middledoi
STED Nanoscopy of the Centrosome Linker Reveals a CEP68-Organized, Periodic Rootletin Network Anchored to a C-Nap1 Ring at Centrioles
Biophysical Journal 2018cited by 4position: middledoi
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
eLife 2017cited by 435position: middledoi
Single-Molecule Localization Microscopy in Eukaryotes
Chemical Reviews 2017cited by 431position: lastdoi
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation
Nature Microbiology 2017cited by 178position: middledoi
Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization
Science Signaling 2017cited by 98position: lastdoi
Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella
EMBO Reports 2017cited by 65position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Christoph Spahn · Goethe University Frankfurt8 papers (2013–2022)Sebastian Malkusch · Goethe University Frankfurt8 papers (2013–2020)Franziska Fricke · Goethe University Frankfurt6 papers (2014–2020)Ulrike Endesfelder · University of Bonn5 papers (2013–2014)Ivan Đikić · Goethe University Frankfurt5 papers (2017–2023)Sjoerd J. L. van Wijk · Goethe University Frankfurt4 papers (2017–2020)Simone Fulda · Goethe University Frankfurt4 papers (2017–2020)Christos Karathanasis · Mortimer Market Centre4 papers (2020–2020)Thomas Kuner · Heidelberg Institute for Theoretical Studies4 papers (2018–2024) · 4 papers (2017–2021)Séamus Holden · University of Warwick3 papers (2013–2022)Roland Eils · University of Michigan3 papers (2015–2018)Erin M. Schuman · Allen Institute for Brain Science3 papers (2014–2022)Alexandre Fürstenberg · University of Geneva3 papers (2013–2020) · 2 papers (2013–2023)Sonja Smith · Goethe University Frankfurt2 papers (2020–2020)Hans‐Georg Kräusslich · Heidelberg University2 papers (2013–2016)Carmen L. Krüger · Goethe University Frankfurt2 papers (2017–2018) · 2 papers (2020–2020)Luke D. Lavis · Howard Hughes Medical Institute2 papers (2018–2018)
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