Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Cancer research, Cell biology, Biology, MAPK/ERK pathway, Chemistry, and Computational biology.
HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics
Data from ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy
Data from ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
An Approach to Bioactivity Assessment for Critical Quality Attribute Identification Based on Antibody-Antigen Complex Structure
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors
Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
Allosteric inhibition of BACE1 by an exosite-binding antibody
NMR Study to Identify a Ligand-Binding Pocket in Ras
Recurrent R-spondin fusions in colon cancer