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Zachary Simmons

Penn State Milton S. Hershey Medical Center · US
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Area of research
Neurology · Genetics
Research interest
Research interests include Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, Parkinson's Disease Mechanisms and Treatments, and Genetic Neurodegenerative Diseases.
h-index
56
citations
12,218
works
310
NIH funding
primary concept
email

Recent publications

TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience 2025cited by 16position: middledoi
Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis
JAMA Network Open 2025cited by 15position: middledoi
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature 2024cited by 4position: middledoi
COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2023cited by 14position: middledoi
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature 2022cited by 499position: middledoi
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
Communications Biology 2022cited by 50position: middledoi
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
iScience 2021cited by 49position: middledoi
Ethical Considerations in Dementia Diagnosis and Care
Neurology 2021cited by 41position: middledoi
Structural and functional characterization of fosfomycin resistance conferred by <scp>FosB</scp> from <scp><i>Enterococcus faecium</i></scp>
Protein Science 2021cited by 6position: middledoi
<scp>COVID‐19–associated Guillain‐Barré</scp> syndrome: The early pandemic experience
Muscle & Nerve 2020cited by 280position: middledoi
Primary lateral sclerosis: consensus diagnostic criteria
Journal of Neurology Neurosurgery & Psychiatry 2020cited by 237position: middledoi
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
JAMA Neurology 2020cited by 136position: middledoi
Clinical features of <scp>LRP4</scp>/agrin‐antibody–positive myasthenia gravis: A multicenter study
Muscle & Nerve 2020cited by 84position: middledoi
Amyotrophic lateral sclerosis care and research in the United States during the <scp>COVID</scp>‐19 pandemic: Challenges and opportunities
Muscle & Nerve 2020cited by 59position: middledoi
A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of <i>Reldesemtiv</i> In Patients With ALS
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2020cited by 56position: middledoi
Preface: promoting research in PLS: current knowledge and future challenges
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2020cited by 15position: middledoi
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Cell Reports 2019cited by 328position: middledoi
Primary lateral sclerosis (PLS) functional rating scale: PLS‐specific clinimetric scale
Muscle & Nerve 2019cited by 34position: middledoi
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
eLife 2018cited by 87position: middledoi
Amyotrophic lateral sclerosis
Nature Reviews Disease Primers 2017cited by 1,359position: middledoi
Hydration measured by doubly labeled water in ALS and its effects on survival
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2017cited by 14position: middledoi
Pain in amyotrophic lateral sclerosis: Patient and physician perspectives and practices
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2015cited by 42position: lastdoi
Relationship of creatine kinase to body composition, disease state, and longevity in ALS
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2015cited by 30position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Dwight E. Matthews · University of Vermont2 papers (2015–2017)Edward J. Kasarskis · University of Kentucky2 papers (2015–2017)Leonard H. van den Berg · Utrecht University2 papers (2017–2020)Hiroshi Mitsumoto · Columbia University Irving Medical Center2 papers (2015–2017)Rup Tandan · University of Vermont2 papers (2015–2017)Mark B. Bromberg · University of Utah2 papers (2015–2017)James D. Berry · Buffalo State University1 papers (2020–2020)Ammar Al‐Chalabi · Cambridge University Hospitals NHS Foundation Trust1 papers (2017–2017) · 1 papers (2021–2021) · 1 papers (2020–2020)Ariane Lewis · John Wiley & Sons (United States)1 papers (2021–2021)Nathan Carberry · University of Miami1 papers (2020–2020)Merit Cudkowicz · Harvard University1 papers (2020–2020)Jeffrey D. Rothstein · German Center for Neurodegenerative Diseases1 papers (2020–2020)Martin R. Turner · University of Oxford1 papers (2020–2020)Giancarlo Logroscino · University of Bari Aldo Moro1 papers (2017–2017) · 1 papers (2021–2021)Matthew K. Thompson · North Carolina State University1 papers (2021–2021)James B. Caress · University of Virginia1 papers (2020–2020)Stefan M. Pulst · University of Utah1 papers (2015–2015)
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