Area of research
Molecular Biology · Geriatrics and Gerontology
Research interest
Research interests include Sirtuins and Resveratrol in Medicine, Mitochondrial Function and Pathology, Cancer, Hypoxia, and Metabolism, and Redox biology and oxidative stress.
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment
SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis
Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis
Circadian Clock NAD <sup>+</sup> Cycle Drives Mitochondrial Oxidative Metabolism in Mice
SIRT2 directs the replication stress response through CDK9 deacetylation
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts