Wenzhao Guan

Area of research

Infectious Diseases · Cancer Research

Research interest

Research topics from publications: MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway; Modulating dual carrier-transfer channels and band structure in carbon nitride to amplify ROS storm for enhanced cancer photodynamic therapy; Identification of diagnostic markers related to fecal and plasma metabolism in primary Sjögren's syndrome. Representative work: BACKGROUND: Studies have shown that microRNA-191 (miR-191) is involved in the development and progression of a variety of tumors. However, the function and mechanism of miR-191 in oral squamous cell carcinoma (OSCC) have not been clarified. METHODS: The expression level of miR-191 in tumor tissues of patients with primary OSCC and OSCC cell lines were detected using real-time quantitative polymerase chain reaction (RT-qPCR) and western blot. OSCC cells were treated with miR-191 enhancers and inhibitors to investigate the effects of elevated or decreased miR-191 expression on OSCC cells proliferation, migration, cell cycle, and tumorigenesis. The target gene of miR-191 in OSCC cells were anal Graphite carbon nitride (CN) eliminates cancer cells by converting H 2 O 2 to highly toxic •OH under visible light. However, its in vivo applications are constrained by insufficient endogenous H 2 O 2 , accumulation of OH − and finite photocarriers. We designed Fe/N V -CN, co-modified CN with nitrogen vacancies (N V ) and ferric ions (Fe 3+ ). N V and Fe 3+ , not only adjust the band structure of CN through quantum confinement effect and the altered coupled oscillations of atomic orbitals to facilitates •OH production by oxidizing OH − , but also construct dual carrier-transfer channels for electrons and holes to respective active sites by introducing stepped electrostatic potential and shor

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