Area of research
Cardiology and Cardiovascular Medicine · Genetics
Research interest
Research interests include Cardiomyopathy and Myosin Studies, Genetic Associations and Epidemiology, Cardiovascular Function and Risk Factors, and Cardiovascular Effects of Exercise.
Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings
Aficamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Safety and Efficacy of Metabolic Modulation With Ninerafaxstat in Patients With Nonobstructive Hypertrophic Cardiomyopathy
Efficacy and Safety of Aficamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4
Impact of Aficamten on Disease and Symptom Burden in Obstructive Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy detection with artificial intelligence electrocardiography in international cohorts: an external validation study
Cardiac biomarkers and effects of aficamten in obstructive hypertrophic cardiomyopathy: the SEQUOIA-HCM trial
Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA‐HCM
A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome
Genetic therapies for cardiomyopathy: survey of attitudes of the patient community for the CureHeart project
Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
The penetrance of rare variants in cardiomyopathy-associated genes: A cross-sectional approach to estimating penetrance for secondary findings
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Aficamten for Drug-Refractory Severe Obstructive Hypertrophic Cardiomyopathy in Patients Receiving Disopyramide: REDWOOD-HCM Cohort 3
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials
Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes
Predictors of Major Atrial Fibrillation Endpoints in the National Heart, Lung, and Blood Institute HCMR
Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification
Whole-genome sequencing of patients with rare diseases in a national health system
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy
Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy
Heterozygous <i>ABCG5</i> Gene Deficiency and Risk of Coronary Artery Disease