Area of research
Cell Biology · Molecular Biology
Research interest
Research interests include Hemoglobin structure and function, Heme Oxygenase-1 and Carbon Monoxide, Hemoglobinopathies and Related Disorders, and Neonatal Health and Biochemistry.
Haptoglobin and Hemopexin Redirect Heme-Driven Oxidative Stress and Neurotoxicity in Organotypic Brain Slices.
An ontogeny-cytokine code determines macrophage response polarity and tumor outcomes.
Cerebrospinal fluid haemoglobin as a monitoring biomarker for secondary brain injury after aneurysmal subarachnoid haemorrhage: prospective international multicentre validation study (HeMoVal)
Sickle cell disease-associated pulmonary hypertension: an integrated framework linking pathologies, mechanisms, and clinical phenotypes
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep.
Patterns of hemolysis, erythropoiesis, and iron distribution define unique disease trajectories in three mouse models of genetic anemia.
Stress-NRF2 response axis polarizes tumor macrophages and undermines immunotherapy.
A CSF-cytokine code predicts macrophage response polarity and tumor outcomes
A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy
Navigating Hemolysis and the Renal Implications of Hemoglobin Toxicity in Cardiac Surgery.
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury.
Effect of a nurse-led integrated care intervention on quality of life and rehospitalisation in patients with severe exacerbation of COPD-a pilot study.
Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation.
Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance.
Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity.
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
VEXAS Syndrome With Tracheal Involvement but Absence of Vasculitis in FDG PET/CT.
Clinical potential of automated convolutional neural network-based hematoma volumetry after aneurysmal subarachnoid hemorrhage.
Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity.
Targeting Metabolic Vulnerabilities to Overcome Prostate Cancer Resistance: Dual Therapy with Apalutamide and Complex I Inhibition.
Association between iron deficiency and hospitalization rate in community-dwelling older adults: A 3-year prospective observational study of DO-HEALTH.
Haptoglobin attenuates cerebrospinal fluid hemoglobin-induced neurological deterioration in sheep
Haptoglobin attenuates cerebrospinal fluid hemoglobin-induced neurological deterioration in sheep
Transcriptomic gene profiles in an
<i>ex vivo</i>
model of erythropoiesis to unravel molecular pathomechanisms of Sickle Cell Disease
Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics.
Erythrophagocytes in hemolytic anemia, wound healing, and cancer.
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease.
Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.
Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain.