Area of research
Molecular Biology · Neurology
Research interest
Research interests include Neuroblastoma Research and Treatments, Genomics and Chromatin Dynamics, Protein Degradation and Inhibitors, and RNA modifications and cancer.
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Specific oncogene activation of the cell of origin in mucosal melanoma
Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance
Regulatory architecture of housekeeping genes is driven by promoter assemblies
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
Predicting master transcription factors from pan-cancer expression data
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
Coactivator condensation at super-enhancers links phase separation and gene control
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
The long noncoding RNA <i>Wisper</i> controls cardiac fibrosis and remodeling
<i>MYC</i> Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification