Area of research
Structural Biology · Surfaces, Coatings and Films
Research interest
Research interests include Advanced Electron Microscopy Techniques and Applications, Electron and X-Ray Spectroscopy Techniques, RNA and protein synthesis mechanisms, and Bacteriophages and microbial interactions.
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase.
Applications of visualization technology in the structural sciences.
The 2024 New York City Integrative Structural Biology Symposium.
Cas1-2/3 integration complex, 34 bp foreign DNA with PAM, CRISPR leader-repeat-spacer DNA fragment
Cryo-EM of SARS-CoV-2 nsp13-replication-transcription complex (nsp13-RTC) (no detergent)
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with UTP
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with ATP
Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci
Ensemble cryo-EM reveals conformational states of the nsp13 helicase replication-transcription complex
Cas1-Cas2/3 heterohexamer bound to foreign dsDNA fragment
Cryo-EM of SARS-CoV-2 nsp13-replication-transcription complex (nsp13-RTC)
Single-particle cryo-electron microscopy of the Cas1-2/3 heterohexamer
Cryo-EM of SARS-SoV-2 pre-incorporation replication-transcription complex with GTP
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with CTP
Cas1-2/3 integration complex, 32 bp foreign DNA without PAM, CRISPR leader-repeat-spacer DNA fragment
Promiscuous G-protein activation by the calcium-sensing receptor
Promiscuous G-protein activation by the calcium-sensing receptor.
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.
Recent advances in infectious disease research using cryo-electron tomography
Applying 3D ED/MicroED workflows toward the next frontiers.
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
Multi-species cryoEM calibration and workflow verification standard.
CryoCycle your grids: Plunge vitrifying and reusing clipped grids to advance cryoEM democratization
Multi-species cryoEM calibration and workflow verification standard
CryoEM of E. coli RNA polymerase and lambda PR promoter DNA 500 ms after mixing (8 mM CHAPSO)
CryoCycle your grids: Plunge vitrifying and reusing clipped grids to advance cryoEM democratization
CryoEM of E. coli RNA polymerase on lambda PR -5G to -5C promoter DNA
CryoEM of E. coli RNA polymerase and lambda PR promoter DNA at equilibrium at 5 degrees Celsius
CryoEM of E. coli RNA polymerase and lambda PR promoter DNA 120 ms after mixing
CryoEM of E. coli RNA polymerase and lambda PR promoter DNA 500 ms after mixing (1.5 mM FC8F)