Area of research
Genetics · Endocrinology, Diabetes and Metabolism
Research interest
is the cause and prevention of type 2 diabetes and cardiovascular disease using biochemical and genetic epidemiology and health services translational research approaches. In 2009 he was awarded the ADA’s prestigious Kelly West Award for Outstanding Achievement in Diabetes Epidemiology. He is a senior leader of many major large international T2D genomics consortia, including MAGIC, DIAGRAM, AAGILE, CHARGE- and TOPMed-diabetes, NIDDK T2D AMP/CMD and the VA’s MVP cardiometabolic work group, and is the PI, co-PI or co-investigator on many NIH grants, currently including UM1 DK078616-13 TOPMed Omics of T2D and Quantitative traits and R01 HL151855-01 TOPMed Omics of CVD in T2D and Quantitative traits. He has formally mentored over 50 early career investigators, most of whom have remained in aca
Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.
Common genetic variants near
<i>SLC2A2</i>
and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Cardiovascular Risk Estimation Is Suboptimal in People With HIV
Adaptive selection at G6PD and disparities in diabetes complications
Cardiovascular Risk Estimation Is Suboptimal in People With HIV.
Polygenic Risk for Type 2 Diabetes in African Americans
Development of electronic health record based algorithms to identify individuals with diabetic retinopathy
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus
The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes
Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits
Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis
Systematic review of precision subclassification of type 2 diabetes
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus
Polygenic Scores for Longitudinal Prediction of Incident Type 2 Diabetes in an Ancestrally and Medically Diverse Primary Care Network
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
Genome-wide polygenic score to predict chronic kidney disease across ancestries
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization