Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, Sarcoma Diagnosis and Treatment, Mitochondrial Function and Pathology, and Protein Degradation and Inhibitors.
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy
Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
B1a B cells require autophagy for metabolic homeostasis and self-renewal
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Hexokinase 2 Is Targetable for HK1-Negative, HK2-Positive Tumors from a Wide Variety of Tissues of Origin
Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation
Lactate dehydrogenase activity drives hair follicle stem cell activation
Metabolic gatekeeper function of B-lymphoid transcription factors
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State
α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4
Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR