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Lee A. Borthwick

Newcastle University · GB
Area of research
Pulmonary and Respiratory Medicine · Surgery
Research interest
Research interests include Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis, Neonatal Respiratory Health Research, Transplantation: Methods and Outcomes, and Liver physiology and pathology.
h-index
38
citations
5,156
works
118
NIH funding
primary concept
Medicine
email

Recent publications

Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research
Journal of Cystic Fibrosis 2026cited by 1position: contributordoi
Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics
Journal of Clinical Medicine 2025cited by 20position: middledoi
Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics.
2025cited by 13position: contributordoi
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ.
2024cited by 49position: contributordoi
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
2024cited by 25position: contributordoi
Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM
2024cited by 1position: contributordoi
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
2024cited by 1position: contributordoi
<i>Ex-vivo</i> mouse precision cut tumour slices for modelling hepatocellular carcinoma; A 3Rs solution for at-scale drug screening
2024cited by 0position: contributordoi
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation.
2023cited by 244position: contributordoi
Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice.
2023cited by 13position: contributordoi
miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways.
2023cited by 9position: contributordoi
Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model.
2023cited by 3position: contributordoi
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?
2022cited by 13position: contributordoi
Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs.
2022cited by 11position: contributordoi
Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis
2022cited by 7position: contributordoi
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.
2022cited by 5position: contributordoi
The Role of Epithelial Damage in the Pulmonary Immune Response.
2021cited by 87position: contributordoi
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis.
2021cited by 47position: contributordoi
Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells.
2021cited by 16position: contributordoi
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease.
2021cited by 11position: contributordoi
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
2021cited by 0position: contributordoi
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.
2020cited by 102position: contributordoi
The circadian clock protein REVERBα inhibits pulmonary fibrosis development.
2020cited by 76position: contributordoi
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis.
2020cited by 71position: contributordoi
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
Nature Metabolism 2020cited by 39position: middledoi
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
2020cited by 31position: contributordoi
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.
2020cited by 18position: contributordoi
Pellino-1 Regulates the Responses of the Airway to Viral Infection.
2020cited by 12position: contributordoi
Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI.
2020cited by 7position: contributordoi
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis.
2020cited by 6position: contributordoi

Grants

No grants ingested yet.

Frequent collaborators

Fiona Oakley · Medical University of Vienna12 papers (2019–2024)Derek A. Mann · Thomas Jefferson University Hospital8 papers (2019–2021)Andrew J. Fisher · KU Leuven5 papers (2020–2023)Marco Y. W. Zaki · Deraya University4 papers (2020–2023)Thomas A. Wynn · Durham University3 papers (2013–2023)Jack Leslie · Wellcome Centre for Mitochondrial Research3 papers (2020–2021)Julie C. Worrell · Centre for Immunity, Infection and Evolution3 papers (2020–2021)Thomas G. Bird · University Hospitals Bristol and Weston NHS Foundation Trust3 papers (2020–2024)Colin Nixon · Foster Care Associates Scotland3 papers (2020–2024)William E. Scott · NIHR Newcastle Biomedical Research Centre3 papers (2019–2023)Amy Collins · University of Newcastle Australia3 papers (2020–2024)Peter Carmeliet · KU Leuven2 papers (2020–2021)Morten Karsdal · Takeda (Denmark)2 papers (2020–2021)Alexander M. S. Barron · Pfizer (United States)2 papers (2022–2023)Martin K Rutter · Oxford Centre for Diabetes, Endocrinology and Metabolism2 papers (2019–2020) · 2 papers (2020–2021)Sandra Murphy · Charles River Laboratories (Netherlands)2 papers (2020–2021)James A. M. Shaw · Newcastle University2 papers (2024–2026) · 2 papers (2022–2023)Christopher M Morris · Research Network (United States)2 papers (2023–2024)