Area of research
Surfaces, Coatings and Films · Ocean Engineering
Research interest
Research topics from publications: Quantitative fabrication, performance optimization and comparison of PEG and zwitterionic polymer antifouling coatings; Biocompatible and antifouling coating of cell membrane phosphorylcholine and mussel catechol modified multi-arm PEGs; Substrate independent coating formation and anti-biofouling performance improvement of mussel inspired polydopamine. Representative work: The design and easy fabrication of biocompatible and antifouling coatings on different materials are extremely important for biotechnological and biomedical devices. Here we report a substrate-independent biomimetic modification strategy for fabricating a biocompatible and antifouling ultra-thin coating. Cell membrane antifouling phosphorylcholine (PC) and/or mussel adhesive catechol (c) groups are grafted at the amino-ends of an 8-armed poly(ethylene glycol). The PC groups are introduced by grafting a random copolymer bearing both PC and active ester groups. The modified 8-arm PEGs (PEG-2c-23PC, PEG-6c-23PC and PEG-8c) anchor themselves onto various substrates from aqueous solution and form oxidation, heating in air and grafting with a phosphorylcholine copolymer bearing active ester groups. The modified surfaces are characterized by X-ray photoelectron spectroscopy (XPS) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy measurements. Interestingly, all the treatments help to resist protein adsorption significantly. More excitingly, the simple grafting strategy with a phosphorylcholine copolymer can resist more than 99% of platelet, fibroblast, and bacteria cell attachment, 98% of bovine serum albumin and 95% of bovine plasma fibrinogen adsorption on the PDA coating. These results may find applications in the vast area of surface antifouling, es
Quantitative fabrication, performance optimization and comparison of PEG and zwitterionic polymer antifouling coatings
Biocompatible and antifouling coating of cell membrane phosphorylcholine and mussel catechol modified multi-arm PEGs
Substrate independent coating formation and anti-biofouling performance improvement of mussel inspired polydopamine