Area of research
Genetics · Molecular Biology
Research interest
is aimed at unraveling the causal genetic factors behind some hereditary diseases. How does variation in hereditary material lead to disease and how can we use such knowledge to prevent or treat diseases? My PhD research focused on a relatively simple genetic disorder that is inherited according to Mendelian laws. In 1995, I was one of the first to take up the challenge of searching for the genetic factors that determine more complex disorders. My group adopted a hypothesis-generating, genome-wide approach, and was able to make great progress on elucidating the genetic factors for celiac disease, intracranial aneurysms, type 2 diabetes and celiac disease. We are now working on systems genetics approaches towards understanding complex diseases and innovative organ-on-chip models for functio
Human organoids and organ-on-chips in coeliac disease research.
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking
Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk.
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation.
Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells
Synergy between culturomics and metagenomics of health status-associated gut bacteria originating from non-IBD and IBD populations.
Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells.
Productivity changes during the COVID-19 pandemic and its associated risk factors.
Microbial Adaptation in Healthy Ageing: Insights from Age-associated Structural Variation in the Human Gut Microbiome
Host genetic regulation of human gut microbial structural variation.
An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells.
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
Transmission and dynamics of mother-infant gut viruses during pregnancy and early life.
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses.
Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data.
Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content
Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing.
NMR metabolomics-guided DNA methylation mortality predictors.
Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study.
Microbiome-wide PheWAS links gut microbial SNVs to human health and exposures
Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation
Author Correction: Symptoms and quality of life before, during, and after a SARS‑CoV‑2 PCR positive or negative test: data from Lifelines.
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.
OTTERS: a powerful TWAS framework leveraging summary-level reference data
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.
Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures.
OTTERS: a powerful TWAS framework leveraging summary-level reference data.