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Jay W. Heinecke

University of Washington · US
Area of research
Immunology · Endocrinology, Diabetes and Metabolism
Research interest
Research interests include Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Diabetes, Cardiovascular Risks, and Lipoproteins, Nitric Oxide and Endothelin Effects, and Antioxidant Activity and Oxidative Stress.
h-index
109
citations
37,623
works
355
NIH funding
primary concept
email

Recent publications

Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL
Journal of Lipid Research 2025cited by 6position: middledoi
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
Alzheimer s & Dementia 2024cited by 29position: middledoi
Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs
Circulation 2023cited by 34position: lastdoi
ABCA1 is an extracellular phospholipid translocase
Nature Communications 2022cited by 56position: lastdoi
Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice
Circulation Research 2021cited by 29position: middledoi
Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease
Diabetes 2020cited by 236position: middledoi
Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation
Circulation 2019cited by 106position: middledoi
Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein
Molecular & Cellular Proteomics 2019cited by 29position: lastdoi
A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state
Nature Structural & Molecular Biology 2017cited by 73position: middledoi
Plasminogen promotes cholesterol efflux by the ABCA1 pathway
JCI Insight 2017cited by 43position: middledoi
Dysfunctional HDL and atherosclerotic cardiovascular disease
Nature Reviews Cardiology 2015cited by 789position: middledoi
Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway
Journal of Lipid Research 2015cited by 57position: lastdoi
Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion
Journal of Biological Chemistry 2015cited by 33position: lastdoi
Humans With Atherosclerosis Have Impaired ABCA1 Cholesterol Efflux and Enhanced High-Density Lipoprotein Oxidation by Myeloperoxidase
Circulation Research 2014cited by 190position: lastdoi
Quantification of HDL Particle Concentration by Calibrated Ion Mobility Analysis
Clinical Chemistry 2014cited by 93position: lastdoi
An Experimentally Robust Model of Monomeric Apolipoprotein A-I Created from a Chimera of Two X-ray Structures and Molecular Dynamics Simulations
Biochemistry 2014cited by 29position: lastdoi
High-density lipoproteins: A consensus statement from the National Lipid Association
Journal of clinical lipidology 2013cited by 338position: middledoi
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1
Proceedings of the National Academy of Sciences 2012cited by 306position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Tomáš Vaisar · University of Washington8 papers (2014–2025)Karin Bornfeldt · New York University7 papers (2012–2025)Jere P. Segrest · University of Alabama at Birmingham6 papers (2014–2025)W. Sean Davidson · The University of Texas Southwestern Medical Center5 papers (2013–2025) · 4 papers (2014–2017)Hyun D. Song · Indiana University – Purdue University Indianapolis4 papers (2017–2023)Ira J. Goldberg · NYU Langone Health4 papers (2019–2023) · 4 papers (2014–2017)Patrick M. Hutchins · University of Colorado Denver4 papers (2014–2023)Chongren Tang · University of Washington4 papers (2014–2023)Yi He · Twitter (United States)3 papers (2014–2023)Martin K. Jones · University of Alabama at Birmingham3 papers (2014–2022)Anatol Kontush · Inserm2 papers (2013–2015)Catherine A. Reardon · University of Illinois Chicago2 papers (2015–2017)Lev Becker · MEI Pharma (United States)2 papers (2012–2015)Robert S. Rosenson · Montreal Heart Institute2 papers (2013–2015)M. John Chapman · University of Cambridge2 papers (2013–2015)Michael N. Oda · US Biologic (United States)2 papers (2014–2017)Edward A. Fisher · Institute for Biomedical Engineering2 papers (2019–2021)Jenny E. Kanter · Seattle University2 papers (2012–2021)