Area of research
Genetics · Oncology
Research interest
Research interests include Virus-based gene therapy research, CAR-T cell therapy research, CRISPR and Genetic Engineering, and Immune Cell Function and Interaction.
Multiple arterial aneurysms involving the thoracoabdominal aorta and renal arteries in a young patient with possible heritable etiology: Two-stage open surgical repair management.
T cells dressed up with a dual HLA-restricted TCR targeting cathepsin G drive effective AML eradication.
TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome.
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation.
Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes.
Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes.
Spatiotemporal liver dynamics shape hepatocellular heterogeneity and impact in vivo gene engineering.
Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma.
A novel mouse model recapitulates the effects of rs2254524 variant in the lanosterol synthase gene on salt sensitivity and organ damage.
Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus.
Liver fibrosis negatively impacts in vivo gene transfer to hepatocytes
Acute and Chronic Manifestations of Sympathetic Ophthalmia on Multimodal Imaging.
Microbiome Modulation Uncouples Efficacy and Toxicity Induced by Programmed Death-1/Programmed Death-Ligand1 Blockade
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases.
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders.
Scalable GMP-compliant gene correction of CD4+ T cells with IDLV template functionally validated in vitro and in vivo
Interleukin-6 inhibition for the treatment of IgG4 related vasculitis.
Cerebral Thrombus Analysis in Infective Endocarditis: Unveiling Composition for Diagnostic Insight
<i>ΔF508-Cftr</i> mutation in genetically diverse Collaborative Cross mice yields novel disease-relevant phenotypes for cystic fibrosis
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies.
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models.
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function.
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients.
New TMA (4,6,4'-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease.
New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease
Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.