Area of research
Public Health, Environmental and Occupational Health · Pediatrics, Perinatology and Child Health
Research interest
Research interests include Biology, Medicine, Genetics, Lymphoblastic Leukemia, Leukemia, and Thiopurine methyltransferase.
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
A new genomic framework to categorize pediatric acute myeloid leukemia
Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations
Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia
Clinical Actionability of the <i>NUDT15</i> *<i>4</i> (p.<scp>R139H</scp>) Allele and Its Association With Hispanic Ethnicity
Bootstrap Evaluation of Association Matrices (BEAM) for Integrating Multiple Omics Profiles with Multiple Outcomes
Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia
The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21
Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators
Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia
Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia
Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia
Effects of arabinoxylan and chlorogenic acid on the intestinal microbiota in dextran sulfate sodium–treated mice
Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia
Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia
Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia
Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia
Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine
Massively parallel variant characterization identifies<i>NUDT15</i>alleles associated with thiopurine toxicity
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
Molecular basis of <i>ETV6</i>-mediated predisposition to childhood acute lymphoblastic leukemia
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome
Multiplex assessment of protein variant abundance by massively parallel sequencing
Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia
Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics