Area of research
Physiology · Molecular Biology
Research interest
Research interests include Alzheimer's disease research and treatments, Protein Structure and Dynamics, Computational Drug Discovery Methods, and Prion Diseases and Protein Misfolding.
Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges
Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson’s disease and multiple system atrophy
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy
The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
Three‐repeat and four‐repeat tau isoforms form different oligomers
CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
A Label-Free Platform for Identification of Exosomes from Different Sources
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator
Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation
Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos
Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03
A molecular tweezer antagonizes seminal amyloids and HIV infection
Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer
A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease
A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity
Comparison of Three Amyloid Assembly Inhibitors: The Sugar <i>scyllo-</i>Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers
Modulating Self‐Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms
Effects of different amyloid β-protein analogues on synaptic function