Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Muscle Physiology and Disorders, Genetic Neurodegenerative Diseases, Adipose Tissue and Metabolism, and Calpain Protease Function and Regulation.
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan
N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
<i>Large1</i> gene transfer in older <i>myd</i> mice with severe muscular dystrophy restores muscle function and greatly improves survival
Muscular dystrophy-dystroglycanopathy in a family of Labrador retrievers with a LARGE1 mutation
POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan
HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan
Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation
Structural basis of laminin binding to the LARGE glycans on dystroglycan
Structure of protein O-mannose kinase reveals a unique active site architecture
The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation
Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-Dystroglycan in Cells and Tissues
SGK196 Is a Glycosylation-Specific <i>O</i> -Mannose Kinase Required for Dystroglycan Function
LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy
ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome