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X. Cynthia

Jewish Hospital · US
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Area of research
Pulmonary and Respiratory Medicine · Oncology
Research interest
Research interests include Advanced Breast Cancer Therapies, HER2/EGFR in Cancer Research, Cancer Treatment and Pharmacology, and Cancer Genomics and Diagnostics.
h-index
67
citations
17,103
works
641
NIH funding
primary concept
Medicine
email

Recent publications

First-Line Camizestrant for Emerging <i>ESR1</i> -Mutated Advanced Breast Cancer
New England Journal of Medicine 2025cited by 94position: middledoi
Patient-reported outcomes in the SERENA-6 trial of camizestrant plus CDK4/6 inhibitor in patients with advanced breast cancer and emergent ESR1 mutations during first-line endocrine-based therapy
Annals of Oncology 2025cited by 4position: middledoi
PACE: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab After Progression on Cyclin-Dependent Kinase 4/6 Inhibitor and Aromatase Inhibitor for Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor–Negative Metastatic Breast Cancer
Journal of Clinical Oncology 2024cited by 106position: middledoi
Imlunestrant, an Oral Selective Estrogen Receptor Degrader, as Monotherapy and in Combination With Targeted Therapy in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Phase Ia/Ib EMBER Study
Journal of Clinical Oncology 2024cited by 33position: middledoi
Endocrine-Sensitive Disease Rate in Postmenopausal Patients With Estrogen Receptor–Rich/ERBB2-Negative Breast Cancer Receiving Neoadjuvant Anastrozole, Fulvestrant, or Their Combination
JAMA Oncology 2024cited by 18position: firstdoi
Abstract PS17-06: A phase I trial of the PI3K inhibitor (PI3Ki) copanlisib and fulvestrant in combination with continuous or intermittent abemaciclib in patients with estrogen receptor-positive (ER+), HER2-negative (HER2-) metastatic breast cancer
Cancer Research 2024cited by 0position: firstdoi
Design of SERENA-6, a phase III switching trial of camizestrant in <i>ESR1</i> -mutant breast cancer during first-line treatment
Future Oncology 2023cited by 75position: middledoi
Neratinib + fulvestrant + trastuzumab for HR-positive, HER2-negative, HER2-mutant metastatic breast cancer: outcomes and biomarker analysis from the SUMMIT trial
Annals of Oncology 2023cited by 58position: middledoi
Abstract GS3-06: GS3-06 Palbociclib After CDK4/6i and Endocrine Therapy (PACE): A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for Endocrine Pre-treated ER+/HER2- Metastatic Breast Cancer
Cancer Research 2023cited by 57position: middledoi
379MO Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): Updated results from BEGONIA, a phase Ib/II study
Annals of Oncology 2023cited by 44position: middledoi
Abstract GS3-03: GS3-03 ARV-471, a PROTAC® estrogen receptor (ER) degrader in advanced ER-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer: phase 2 expansion (VERITAC) of a phase 1/2 study
Cancer Research 2023cited by 34position: middledoi
A Gene Panel Associated With Abemaciclib Utility in <i>ESR1</i>-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression
JCO Precision Oncology 2023cited by 16position: middledoi
A phase 1a/b trial of imlunestrant (LY3484356), an oral selective estrogen receptor degrader (SERD) in ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Monotherapy results from EMBER.
Journal of Clinical Oncology 2022cited by 39position: middledoi
Neratinib plus fulvestrant plus trastzuzumab (N+F+T) for hormone receptor-positive (HR+), HER2-negative, <i>HER2</i>-mutant metastatic breast cancer (MBC): Outcomes and biomarker analysis from the SUMMIT trial.
Journal of Clinical Oncology 2022cited by 14position: middledoi
Intermittent fasting in the prevention and treatment of cancer
CA A Cancer Journal for Clinicians 2021cited by 160position: middledoi
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
Nature Communications 2021cited by 108position: middledoi
Serial single-cell genomics reveals convergent subclonal evolution of resistance as patients with early-stage breast cancer progress on endocrine plus CDK4/6 therapy
Nature Cancer 2021cited by 89position: middledoi
Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (“METRIC”): a randomized multicenter study
npj Breast Cancer 2021cited by 53position: middledoi
Microscaled proteogenomic methods for precision oncology
Nature Communications 2020cited by 120position: middledoi
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Nature Cancer 2020cited by 110position: middledoi
Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic
npj Breast Cancer 2020cited by 57position: middledoi
Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy
JNCI Journal of the National Cancer Institute 2020cited by 48position: middledoi
Triplet therapy (continuous ribociclib, everolimus, exemestane) in HR+/HER2− advanced breast cancer postprogression on a CDK4/6 inhibitor (TRINITI-1): Efficacy, safety, and biomarker results.
Journal of Clinical Oncology 2019cited by 43position: middledoi
Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy
Cancers 2019cited by 13position: middledoi
Abstract CT015: Phase I dose-escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer
Cancer Research 2019cited by 1position: middledoi
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
Nature Genetics 2018cited by 237position: middledoi
Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study
British Journal of Cancer 2018cited by 120position: middledoi
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
Cell Reports 2018cited by 109position: middledoi
Evaluation of [89Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer
Breast Cancer Research and Treatment 2018cited by 80position: middledoi
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER <sup>+</sup> breast cancer
The FASEB Journal 2018cited by 31position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Sara A. Hurvitz · University of Washington Applied Physics Laboratory5 papers (2019–2023)Cynthia Huang Bartlett · Pfizer (United States)4 papers (2018–2025)Matthew J. Ellis · West Virginia University4 papers (2016–2020)Erica L. Mayer · Harvard University4 papers (2018–2025)Jeremy Hoog · Washington University in St. Louis4 papers (2017–2018)Massimo Cristofanilli · NewYork–Presbyterian Brooklyn Methodist Hospital4 papers (2018–2025)Adam Brufsky · UPMC Hillman Cancer Center3 papers (2022–2025)Zbigniew Nowecki · Institute of Cardiology3 papers (2023–2025)Nicholas C. Turner · Queensland University of Technology3 papers (2023–2025)Eric P. Winer · Yale University3 papers (2017–2018)Michael Naughton · University of Alabama at Birmingham3 papers (2015–2018)Stacy Moulder · Eli Lilly (United States)3 papers (2019–2019)Ron Bose · Alvin J. Siteman Cancer Center3 papers (2016–2022)Rita Nanda · Sun Pharma (India)3 papers (2014–2023)Hiroji Iwata · Juntendo University3 papers (2023–2025)Matthew P. Goetz · Mayo Clinic3 papers (2014–2017)Ian E. Krop · Cancer Institute (WIA)3 papers (2017–2019)Jingqin Luo · John Wiley & Sons (United States)2 papers (2017–2024)Matthias Ocker · Charité - Universitätsmedizin Berlin2 papers (2019–2019)Komal Jhaveri · Weatherford College2 papers (2022–2022)
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