Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiac electrophysiology and arrhythmias, Ion channel regulation and function, Neuroscience and Neural Engineering, and ECG Monitoring and Analysis.
Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology.
Stem cell-derived cardiomyocyte heterogeneity confounds electrophysiological insights.
Optimization of a cardiomyocyte model illuminates role of increased <i>I</i><sub>Na,L</sub> in repolarization reserve.
Single-cell ionic current phenotyping elucidates non-canonical features and predictive potential of cardiomyocytes during automated drug experiments.
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings
Optimization of a Cardiomyocyte Model Illuminates Role of Increased I <sub>NaL</sub> in Repolarization Reserve
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
A dual <i>SHOX2:GFP; MYH6:mCherry</i> knockin hESC reporter line for derivation of human SAN-like cells.
Leak current, even with gigaohm seals, can cause misinterpretation of stem-cell derived cardiomyocyte action potential recordings
A model-guided pipeline for drug cardiotoxicity screening with human stem-cell derived cardiomyocytes
Calibration of ionic and cellular cardiac electrophysiology models
Calibration of ionic and cellular cardiac electrophysiology models.
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity.
Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia.
Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes
Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI)
Cell-Specific Cardiac Electrophysiology Models
Exploiting mathematical models to illuminate electrophysiological variability between individuals
Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study
Nonlinear Dynamics in Cardiology