Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, Protein Degradation and Inhibitors, and Endoplasmic Reticulum Stress and Disease.
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
Metabolism archetype cancer cells induce protumor TREM2+ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation
Design, Synthesis, and Activity Evaluation of BRD4 PROTAC Based on Alkenyl Oxindole-DCAF11 Pair
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis
Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway
CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether
Dual gene activation and knockout screen reveals directional dependencies in genetic networks
Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length